Influence of Water Extract from  on Lipid Peroxidation Induced by Carbon Tetrachlorile in Mice

LIN Xing; HUANG Quan-fang; ZHANG Shi-junv; LIAO Ming; HUANG Ren-bin

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Influence of Water Extract from on Lipid Peroxidation Induced by Carbon Tetrachlorile in Mice

更新时间：2024-01-04

- Influence of Water Extract from on Lipid Peroxidation Induced by Carbon Tetrachlorile in Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 10, Pages: 147-149(2010)
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- Published：2010
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LIN Xing, HUANG Quan-fang, ZHANG Shi-junv, et al. Influence of Water Extract from on Lipid Peroxidation Induced by Carbon Tetrachlorile in Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(10): 147-149.
DOI：

LIN Xing, HUANG Quan-fang, ZHANG Shi-junv, et al. Influence of Water Extract from on Lipid Peroxidation Induced by Carbon Tetrachlorile in Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(10): 147-149. DOI：

摘要

目的 :研究山芝麻水提物(Helicteres angustifolia)对四氯化碳(CCl4)诱导肝损伤小鼠脂质过氧反应的影响。方法 :以CCl4造成小鼠急性肝损伤模型

山芝麻ig

测定血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)活性、丙二醛(MDA)含量、超氧化物歧化酶(SOD)活性、总抗氧化能力(T-AOC)

以及检测肝组织MDA

SOD

NO和T-AOC含量。结果 :山芝麻能保护CCl4所致小鼠肝损伤

使血清ALT

AST活力和MDA含量下降

SOD活性和T-AOC水平提高。山芝麻还能提高肝组织SOD

T-AOC含量

降低MDA

NO水平。结论 :山芝麻具有抗脂质过氧化作用。

Abstract

Objective: To study anti-lipid peroxidation effects of the water extract from H. angustifolia(HA) on liver damage induced by carbon tetrachlorile (CCl4) in mice. Method: After acute liver injury model was induced by CCl4

mice were administrated intragastrically with water extract of H. angustifolia

the content of alanine transaminase (ALT)

aspartate aminotransferase (AST)

malondialdehyde (MDA) and activity of superoxide dismutase (SOD)

ability of total antioxidation capacity (T-AOC) were measured respectively in serum. The levels of MDA

SOD

T-AOC were evaluated respectively in liver. Result: H. angustifolia could markedly decrease ALT

AST

MDA content

increase SOD activity and ability of T-AOC respectively in serum

also could increase the content of SOD and T-AOC

decrease the levels of MDA and NO respectively in liver. Conclusion: H. angustifolia has the effect of anti-lipid peroxidation.

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Related Institution

The First Affiliated Hospital， Jinan University

School of Traditional Chinese Medicine， Jinan University

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School of Pharmacy，Anhui University of Chinese Medicine & Laboratory of Rearch and Development of Traditional Chinese Medicine in Anhui Province

Gansu Provincial Hospital of Traditional Chinese Medcine

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