Effects of Chai Shao He Wei Granules on Chronic Superficial Gastritis in Mouse Model

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Effects of Chai Shao He Wei Granules on Chronic Superficial Gastritis in Mouse Model

更新时间：2024-09-23

- Effects of Chai Shao He Wei Granules on Chronic Superficial Gastritis in Mouse Model
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 1, Pages: 74-75(2010)
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- Published：2010
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Effects of Chai Shao He Wei Granules on Chronic Superficial Gastritis in Mouse Model[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(1): 74-75.
DOI：

Effects of Chai Shao He Wei Granules on Chronic Superficial Gastritis in Mouse Model[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(1): 74-75. DOI：

摘要

目的: 观察静安口服液对小儿多发性抽动症(Tourette综合征)模型大鼠脑组织、血浆多巴胺(DA)和高香草酸(HVA)含量的影响。方法: Tourette综合征模型用ip DOI(连续20d)的方法

分为空白对照组、模型组、静安口服液组、硫必利组4组。多巴胺(DA)和高香草酸(HVA)用HPLC法测定。结果: 静安口服液能降低脑组织中DA和HVA含量(P<0.01)

作用与硫必利相似。血浆中DA含量极微量

血浆中HVA未检出。结论: 静安口服液模型组大鼠脑组织DA和HVA含量较空白对照组明显升高

而静安口服液、硫必利二组含量较模型组明显降低

因此

推测静安口服液作用机理与调整脑内DA和HVA神经递质

减少DA和HVA的异常释放

从而降低突触前多巴胺神经元的过度支配有关。

Abstract

Objective:To observe the effects of Chai Shao He Wei Granules (CSHW) on chronic superficial gastritis in mouse model induced by methimazole．Methods:Established mice model of chronic superficial gastritis by administrating methimazole for 28 days；Three weeks after drug administration histopathology of gastric mucosa was observed by HE stain．The contents of PGE2，phosphatide and aminohexose in gastric mucosa were detected by chemical colorimetry；and the content of serum gastrin was detected by radioimmunoassay．Results:Compared with model group，CSHW high dose group could reduce the pathological damage of chronic superficial gastritis in mice，increase the content of aminohexose，elevate the levels of PGE2 and phosphatide and reduce the level of gastrin in serum，respectively．Conclusions:CSHW could obviously reduce the inflammation and damage in gastric mucosa of chronic superficial gastritis induced by methimazole in mice and protect the gastric mucosa．The effect may be related to the increase of aminohexose in gastric mucosa，raise of phosphatide and PGE2，reduction of serum gastrin．

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