Study on molding technics of Rujining capsule

DUAN Xiao-ying; YAN Yan-cang; GAO Wei-fang; ZHANG Hui

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Study on molding technics of Rujining capsule

更新时间：2024-09-23

- Study on molding technics of Rujining capsule
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 4, Pages: 4-6(2010)
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- Published：2010
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DUAN Xiao-ying, YAN Yan-cang, GAO Wei-fang, et al. Study on molding technics of Rujining capsule[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(4): 4-6.
DOI：

DUAN Xiao-ying, YAN Yan-cang, GAO Wei-fang, et al. Study on molding technics of Rujining capsule[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(4): 4-6. DOI：

摘要

目的:研究乳疾宁胶囊的成型工艺。方法:考察不同辅料对浸膏粉吸湿性的影响;以颗粒的合格率作为指标

筛选最佳制粒成型工艺条件

并考察颗粒的临界相对湿度

休止角及堆密度。结果: 微晶纤维素为辅料抗湿性能较好

浸膏粉与辅料按7∶3的比例混匀

加入95%乙醇0.25倍制软材;制得颗粒流动性较好

临界相对湿度为50%

堆密度为0.466 g·mL-1。结论:该成型工艺合理、可行

为大生产提供了科学依据。

Abstract

Objective:To study the formation technology of Rujining capsule. Methods: The influence of different excipients on the hygroscopicity of extract powder was investigated by screening the best processing technology conditions and inspecting the critical relative humidity

angle of repose

and bulk density. Result: Microcrystalline cellulose as excipients had a good anti-wet performance

the extract powder and microcrystalline cellulose were mixed evenly in proportion of 7∶3

the 95% alcohol was used as the weting agent

its amount was 25% of extract powder. The granules of end product had a good fluidity

the critical relative humidity was about 50%

bulk density was 0.466 g ·mL-1. Conclusion: The molding technology is reasonable

and can provide reliable basis for production.

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Related Author

DUAN Xiao-ying1

YAN Yan-cang2

GAO Wei-fang2

ZHANG Hui1

MU Hong

LIU Shu-min

YANG Bu-ke

ZHANG Chong

Related Institution

Department of Pharmacy,The First Affiliated Hospital Henan College of Traditional Chinese Medicine

Henan College of Traditional Chinese Medicine

School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine (TCM)

National & Local United Engineering Laboratory for TCM Advanced Manufacturing Technology, Tasly Pharmaceutical Co. Ltd.

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