Objective: To study the pathological damage mechanism of rats

nephrotoxicity after taking a large dose of alcohol extracted components of herba leonuri for a long time. Method: According to 45-day toxicity by experimental methods

to carry out the histopathologic examination of nephridial tissue;to detect the content of MDA

total SH

GSH and activity of SOD

GSH-Px in serum. Result: Histopathological examination shows: the high

medium and low dose group of alcohol extracted components of herba leonuri can induce the different degrees of renal tubular injury

and the damage gradually aggravates with dose increasing; can induce the content of total-SH

MDA in serum increasing

GSH in serum decreasing and the activity of SOD

GSH-Px decreasing in serum

and the above-mentioned change gradually aggravates with dose increasing

and it is the obvious discrepancy compared with control group. Conclusion: The oxidative damage mechanism may be one of the pathological damage mechanisms caused by Herba Leonuri.