An Experimental Study of Guanxinping on Isoprenaline-induced Myocardial Ischemia

WANG Dao-cheng; LI Qi-yi; ZHU Xuan-xuan; YAN Shi-hai; QIN Xiao-kang; MA Jun-jie

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An Experimental Study of Guanxinping on Isoprenaline-induced Myocardial Ischemia

更新时间：2024-01-04

- An Experimental Study of Guanxinping on Isoprenaline-induced Myocardial Ischemia
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 10, Pages: 143-146(2010)
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- Published：2010
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WANG Dao-cheng, LI Qi-yi, ZHU Xuan-xuan, et al. An Experimental Study of Guanxinping on Isoprenaline-induced Myocardial Ischemia[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(10): 143-146.
DOI：

WANG Dao-cheng, LI Qi-yi, ZHU Xuan-xuan, et al. An Experimental Study of Guanxinping on Isoprenaline-induced Myocardial Ischemia[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(10): 143-146. DOI：

摘要

目的:观察冠心平对异丙肾上腺素(ISO)致大鼠心肌缺血的影响。方法:采取大鼠scISO(30 mg·kg-1)致急性心肌缺血模型

观察冠心平对大鼠血清乳酸脱氢酶(LDH)、肌酸磷酸激酶(CK)、丙二醛(MDA)、超氧化物歧化酶(SOD)活性的影响;观察注射ISO后不同时间J点下降情况

心肌病理损伤程度的影响;结果:冠心平各剂量组均可不同程度降低LDH

CK活力降低血清MDA水平

升高SOD水平(P＜0.01

P＜0.05);明显抑制ISO引起的大鼠心电图J点下降(P＜0.05

P＜0.01);心肌病理损伤程度明显减轻。结论:冠心平对ISO致大鼠心肌缺血模型具有明显保护作用。

Abstract

Objective: To observe the effect of Guanxinping on myocardial ischemic injury induced by isoprenaline in rats. Method: Rat myocardial ischemia was induced by subcutaneous injection of isoprenaline(30 mg·kg-1). The effect of Guanxinping on the lactate dehydrogenase (LDH)

serum creatine kinase (CK)

malondial dehyde (MDA)and superoxide dismutase (SOD)was observed. The descent of J point at different time after injection of isoprenaline was examined

and pathological investigation of myocardial injury in rats was carried out. Result: Guanxinping could obviously inhibit the activities of serum CK

LDH

and MDA

enhance serum SOD activity(P＜0.01

P＜0.05). Guanxinping could inhibit descent of J point in rat myocardial ischemia induced by isoprenaline(P＜0.05

P＜0.01)

and significantly reduce the extent of myocardial pathological damage. Conclusion: Guanxinping can obviously ameliorate myocardial ischemic injury induced by isoprenaline in rat.

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Related Institution

安徽中医学院中西医结合临床学院药理学教研室

安徽省现代中药研究中心

Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine

Nanjing University of Chinese Medicine

Hebei Key Laboratory of Chinese Medicine Research on Cardiocerebrovascular Disease

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