Objective: To investigate the effects of Panax notogiuseng(PN)

Gynostemma pentaphyllum(Gp) and their total saponins(PNs and Gps) on vascular remodeling in experimental atherosclerosis rabbit and to explore the possible mechanism. Method: Forty healthy male Zelanian white rabbits were used in the experiment. They were randomly selected and allocated as 5 groups:group 1 nomlal control group

group 2 treated with PN and Gp

group 3 treated with PNs and Gps

group 4 treated with captopril

group 5 positive control group. Normal control group were fed with normal diet

the other groups were fed with hypercnolesterol diet. After administered for 12 weeks

histopathological examination of abdominal aorta with the most obvious lesion was performed

and the changes of related vascular remodeling indexes were observed using computerized image analyzing system. Result: PN and Gp could significantly decreased the number of VSMC(P<0.01). The area of medial membrane of group 2 were significantly lower than that in the positive control group. Conclusions: PN

Gp and their total saponins played its action in preventing and treating atherosclerosis through inhibiting intimal proliferation and intervening pathological vascular remodeling.