Objective: To observe the effect of Qinzao Jiufei recipe and Astragalus membranaceus on radioprotection of lung and expression of plasma transfroming growth factor beta-1 (TGF-β1) and Interleukin-1(IL-1)in partial mid and late stage chest tumor patients with lung radiotherapy. Method : The partial mid and late stage chest tumor patients were randomized into control group and therapy group

therapy group with Qinzao Jiufei recipe 200 mL

po

bid and Astragalus membranaceus 10 mL

po

bid before radiotherapy and continued for 6 mouths

Plasma TGF-β1 and IL-1 were examined before and at the end of radiotherapy

Clinicalsymptoms

lung function and high-resolution computed tomography of thorax were evaluated at 15 days after radiotherapy. Result: Before radiotherapy

plasma TGF-β1 for(4.49±2.01)ng·mL-1 in therapy group and (4.47±2.01)ng·mL-1 in control group

at the end of radiotherapy

the level of plasma TGF-β1 in control group was much higer than in therapy group

before radiotherapy

plasma IL-1 for(24.87±15.03)pg·mL-1 in therapy group and (25.44±17.18)pg·mL-1 in control group

at the end of radiotherapy

the level oplasma IL-1in control group was much higer than in therapy group .Five months and ten months after radiotherapy

patients in the therapy group whose CO diffusion capacity of lung (DLCO) declined were less than those in the control group(P<0.05)

there was significant difference between the two groups.Occurrence rate of radioactive pneumonia and pulmonary fibrosis was significant difference between the two groups(P<0.05). Conclusion: Qinzao Jiufei Recipe and Astragalus membranaceus can inhibit overexpression of plasma TGF-β1and IL-1 after radiotherapy

and may reduce the severity of dysfunction lung injury. Qinzao Jiufei recipe and Astragalus membranaceus can prevent and treat of radioactive lung injuries.