The Study of Anti-bradycardic Effect and Mechanism of Ganfu Granule in Rats

LI Dong; CHEN Zhi-wu; CEN De-yi; WANG Di-sheng

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The Study of Anti-bradycardic Effect and Mechanism of Ganfu Granule in Rats

更新时间：2024-09-23

- The Study of Anti-bradycardic Effect and Mechanism of Ganfu Granule in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 1, Pages: 68-71(2010)
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- Published：2010
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LI Dong, CHEN Zhi-wu, CEN De-yi, et al. The Study of Anti-bradycardic Effect and Mechanism of Ganfu Granule in Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(1): 68-71.
DOI：

LI Dong, CHEN Zhi-wu, CEN De-yi, et al. The Study of Anti-bradycardic Effect and Mechanism of Ganfu Granule in Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(1): 68-71. DOI：

摘要

目的: 探讨甘附冲剂抗大鼠心动过缓的可能作用机制。方法: 用普萘洛尔(Pro)制备大鼠心率减慢模型;测定大鼠心肌组织中谷胱甘肽过氧化物酶(GSH-PX)、超氧化物歧化酶(SOD)的活性及丙二醛(MDA)的含量。放射免疫法测定心肌组织中环磷酸腺苷(cAMP)、环磷酸鸟苷(cGMP)及血浆中降钙素基因相关肽(CGRP)、内皮素(ET)的含量。结果: 30

270 mg·kg-1甘附冲剂可显著抑制Pro引起的大鼠心率减慢(P<0.05或P<0.01)

和心肌组织中MDA含量的升高

提高大鼠血浆CGRP的含量

并可显著降低心肌组织中cGMP的含量

提高cAMP/cGMP比值(P<0.05或P<0.01);90

270 mg·kg-1甘附冲剂可增强大鼠心肌组织中SOD和GSH-PX的活性(P<0.05);甘附冲剂各剂量对大鼠心肌组织中cAMP含量及大鼠血浆ET含量并没有明显影响。结论: 甘附冲剂抗大鼠心动过缓的作用可能与抗自由基、升高CGRP及调节cAMP和cGMP的平衡有关。

Abstract

Objective: To study the anti-bradycardic mechanism of Ganfu granule in rats. Methods: The bradycardic model in rats was induced by propranolol (Pro). the activity of glutathione peroxidase(GSH-PX)

superoxide dismutase (SOD) and the content of Malonydialdehyde (MDA) in heart tissue were detected; the content of cyclic adenosine monophosphate (cAMP)

cyclic guanosine monophosphate (cGMP) in heart tissue as well as the content of calcitonin gene-related peptide (CGRP)

endothelin (ET) in plasma were detected by radioimmunoassay. Results: Ganfu granule (30

270 mg·kg-1) significantly inhibited the Pro-induced decrease of heart rate in rats

reduced the content of MDA

cGMP in heart tissue

markedly increased the content of CGRP in plasma and the ratio of cAMP/cGMP in heart tissue. Gan granule(90

270 mg·kg-1) markedly increased the activity of SOD and GSH-PX in heart tissue; Compare with model group

the changes of the content of ET in plasma and cAMP in heart tissue were not obviouse. Conclusion: The anti-bradycardic mechanism of Ganfu granule may be related to anti-free radicals

increasing CGRP

regulating the balance between cAMP and cGMP.

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Related Author

LI Dong~1

CHEN Zhi-wu~2

CEN De-yi~2

WANG Di-sheng~

Xuan-xuan ZHU

Xiao-qian LIU

Yao-hua LIANG

Li-mei LIN

Related Institution

安徽医科大学

蚌埠医学院第二附属医院

National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines， Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

School of Pharmacy， Hunan University of Chinese Medicine

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