Protective Effect of Jiawei Shengmaisan Against Acute Myocardial Ischemia/Reperfusion Injury in Rats

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Protective Effect of Jiawei Shengmaisan Against Acute Myocardial Ischemia/Reperfusion Injury in Rats

更新时间：2024-09-23

- Protective Effect of Jiawei Shengmaisan Against Acute Myocardial Ischemia/Reperfusion Injury in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 2, Pages: 87-89(2010)
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- Published：2010
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Protective Effect of Jiawei Shengmaisan Against Acute Myocardial Ischemia/Reperfusion Injury in Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(2): 87-89.
DOI：

Protective Effect of Jiawei Shengmaisan Against Acute Myocardial Ischemia/Reperfusion Injury in Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(2): 87-89. DOI：

摘要

目的: 对治疗痛风病疗效确切的院内制剂痛风灵微丸的处方结构进行优化研究

为其临床前研究提供疗效可靠的优化处方

探索中药复方定量优化方法。方法: 运用均匀设计改良法

以特异的药效学指标为评价指标

进行处方最佳配伍和最佳剂量配比的研究。结果: 以均匀设计法得出痛风灵微丸的最佳配伍和最佳剂量配比的处方值。结论: 该实验研究将拆方分析方法与最佳剂量配比研究结合起来

得到了比实践少1味药物的结论

并推荐其用于新药开发研究。

Abstract

Objective: To investigate protective effect of Jiawei Shengmaisan against acute myocardial ischemia/reperfusion injury in rats. Methods: The acute myocardial ischemia/reperfusion injury in rats was induced by ligating the anterior descending coronary artery in SD rats and administered different dosage jiawei shengmaisan decotion into duodenum

myocardial infarction degree(MID) was calculated by detcting myocardial infarction area with nitroblue tetrazolium(NBT) assay

SOD activities and MDA、NO contents were detected with biochemical assay. Results: Jiawei shengmaisan can significantly decreased MID and MDA contents in serum

increased SOD activities and NO contents in serum. Conclusions: The results showed that Jiawei shengmaisan has protective effect against acute myocardial ischemia/reperfusion injury in rats

which may be relate to its antioxygen action and NO.

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Related Author

WANG Ping-jun

ZHENG Qing-shan

WANG Ping jun

ZHENG Qing shan

Related Institution

Yijishan Hospital, Wannan Medical College

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