Effects of Purpura Granules on Levels of Interleukin-11 and Transforming Growth Factor-beta in Peripheral Blood of Mouse Model with Idiopathic Thrombocytopenic Purpura

QIAO Tie; FAN Ying; LIN Shu-ru; MA Ji

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Effects of Purpura Granules on Levels of Interleukin-11 and Transforming Growth Factor-beta in Peripheral Blood of Mouse Model with Idiopathic Thrombocytopenic Purpura

更新时间：2024-01-04

- Effects of Purpura Granules on Levels of Interleukin-11 and Transforming Growth Factor-beta in Peripheral Blood of Mouse Model with Idiopathic Thrombocytopenic Purpura
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 8, Pages: 117-119(2010)
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- Published：2010
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QIAO Tie, FAN Ying, LIN Shu-ru, et al. Effects of Purpura Granules on Levels of Interleukin-11 and Transforming Growth Factor-beta in Peripheral Blood of Mouse Model with Idiopathic Thrombocytopenic Purpura[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(8): 117-119.
DOI：

QIAO Tie, FAN Ying, LIN Shu-ru, et al. Effects of Purpura Granules on Levels of Interleukin-11 and Transforming Growth Factor-beta in Peripheral Blood of Mouse Model with Idiopathic Thrombocytopenic Purpura[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(8): 117-119. DOI：

摘要

目的 :通过观察免疫性血小板减少性紫癜(ITP)模型小鼠外周血白介素-11(IL-11)、转化生长因子(TGF-β1)含量的变化

探讨IL-11

TGF-β1含量变化与ITP发病之间的内在联系。方法: 采用酶联免疫方法检测ITP模型小鼠外周血IL-11

TGF-β1含量变化。结果: 模型组小鼠外周血IL-11

TGF-β1含量明显升高

均有统计学意义(P<0.05)。结论: 调节巨核细胞的正性作用因子IL-11与负性作用因子TGF-β1参与了ITP的发病过程并发挥重要作用

紫癜颗粒通过调控外周血IL-11

TGF-β1的含量变化而达到有效治疗ITP的目的。

Abstract

Objective: To explore the relationship between the changes in interleukin-11(IL-11) and transforming growth factor-beta1(TGF-β1) and occurrence of idiopathic thrombocytopenic purpura(ITP)by investigating content of IL-11 and TGF-β1 in peripheral blood of the mouse model with ITP. Method: Contents of IL-11 and TGF-β1 in peripheral blood of the mouse model with ITP were measured by ELISA. Result: Contents of IL-11 and TGF-β1 in peripheral blood of model group increased significantly

and it was statistically significant(P<0.05). Conclusion: IL-11 and TGF-β1 play an important role in occurrence of ITP

and Purpura Granules can cure ITP effectively by regulating contents of IL-11 and TGF-β1 in peripheral blood.

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