Ultra-performance LC/TOF MS Analysis of Fruits of  for Metabolomic Research

GUO Na; FAN Bin; PENG Juan; YAN Han; MA Fang; YU You-hua

您当前的位置：

首页 >

文章列表页 >

Ultra-performance LC/TOF MS Analysis of Fruits of for Metabolomic Research

更新时间：2024-01-04

- Ultra-performance LC/TOF MS Analysis of Fruits of for Metabolomic Research
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 10, Pages: 131-133(2010)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2010
- 稿件说明：
移动端阅览
GUO Na, FAN Bin, PENG Juan, et al. Ultra-performance LC/TOF MS Analysis of Fruits of for Metabolomic Research[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(10): 131-133.
DOI：

GUO Na, FAN Bin, PENG Juan, et al. Ultra-performance LC/TOF MS Analysis of Fruits of for Metabolomic Research[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(10): 131-133. DOI：

摘要

目的 :建立中药女贞子生品及不同工艺炮制品的代谢组学分析方法

比较研究其指纹图谱差异

探讨女贞子炮制机制。方法 :采用超高效液相-飞行时间质谱(UPLC-Q-TOF-MS)及多元统计分析技术对生品及不同工艺炮制品进行指纹图谱差异比较分析。结果 :生品和不同炮制品指纹图谱存在明显差异

且鉴定了一个产生差异的化学成分标志物- ligustaloside B

其在女贞子炮制品中的含量高于女贞子生品。结论 :UPLC-Q-TOF-MS结合多元统计分析方法可对女贞子药材及其饮片进行质量评价

同时为炮制机制提供了一定依据。

Abstract

Objective: To establish an ultra-performance LC-quadrupole TOF MS (UPLC-Q-TOF-MS) method of the crude and processed fruits of Ligustrum lucidum for metabolomic research

comparative study in their metabolite profiling was performed to explore the mechanism of processing the fruits of L. lucidum. Method: Metabolite profiling of crude and processed fruits of L. lucidum were performed using UPLC-Q-TOF-MS and multivariate statistical analysis technique. Results: There is significant difference of metabolite profiling among the crude and different processed fruits of L. lucidum. The chemical markers such as ligustaloside B for such variations was identified. And its contents in the crude L. lucidum was significantly higher that in the processed one. Conclusions: This study indicated that UPLC-Q-TOF-MS coupled with multivariate statistics is able to provide quality control of the crude and processed fruits of L. lucidum. While the results provide the basis for the mechanism of processing.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Herbal Textual Research on Zanthoxylum armatum and Zanthoxyli Radix in Famous Classical Formulas

Establishment and Evaluation of Rat Model of Myocardial Ischemia-reperfusion Injury with Phlegm and Blood Stasis Blocking Collaterals Syndrome Based on Metabolomics

Establishment and Evaluation of Mouse Model of Cerebral Infarction with Qi and Yin Deficiency Syndrome Based on Metabolomics

Differences and Mechanisms of Combined Use of "Raw and Fried Ziziphi Spinosae Semen" in Anmeidan and Its Disassembled Prescriptions in Improving Anxiety and Cognitive Impairment in Insomnia Rat Model Based on Serum Metabolomics

Effect of Anmeidan on Cognitive Function and Metabolic Profiling in Insomnia Model Rats Based on Untargeted Metabolomics

Related Author

ZENG Zhen

LIU Yanmeng

WANG Yihan

WANG Yapeng

HAO Erwei

YAO Chun

ZHAN Zhilai

HU Longxiao

Related Institution

State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs，National Resource Center for Chinese Materia Medica，China Academy of Chinese Medical Sciences

Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica， Guangxi University of Chinese Medicine

School of Clinical Medicine，Beijing University of Chinese Medicine

Beijing Key Laboratory of Chinese Materia Pharmacology，National Clinical Research Center of Traditional Chinese Medicine for Cardiovascular Diseases，Institute of Basic Medical Sciences， Xiyuan Hospital，China Academy of Chinese Medical Sciences

Natural History Museum of China

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰