Experimental Study on Shuangshenling Granules in Treating Chronic Renal Failure

ZHAO Xiao-xia; MA Tian-tian; ZHANG Yong-li; WU Xiang-jin

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Experimental Study on Shuangshenling Granules in Treating Chronic Renal Failure

更新时间：2024-01-04

- Experimental Study on Shuangshenling Granules in Treating Chronic Renal Failure
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 7, Pages: 115-117(2010)
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- Published：2010
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ZHAO Xiao-xia, MA Tian-tian, ZHANG Yong-li, et al. Experimental Study on Shuangshenling Granules in Treating Chronic Renal Failure[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(7): 115-117.
DOI：

ZHAO Xiao-xia, MA Tian-tian, ZHANG Yong-li, et al. Experimental Study on Shuangshenling Granules in Treating Chronic Renal Failure[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(7): 115-117. DOI：

摘要

目的 :双参苓颗粒为临床治疗慢性肾衰良方

研究其相关药效

为其临床应用提供实验依据。方法: 观察双参苓颗粒ig给药对腺嘌呤所致慢性肾功衰竭大鼠血清尿素氮(BUN)

肌酐(Crea)血瘀大鼠低切变速率下的血液黏度、小鼠肾上腺素致微循环障碍及环磷酰胺致免疫功能低下小鼠的碳廓清指数等的影响。结果: 双参苓颗粒ig给药对腺嘌呤所致慢性肾功衰竭大鼠血清BUN

Crea升高有明显降低作用

明显降低血瘀大鼠低切变速率下的血液黏度

促进肾上腺素致微循环障碍的恢复

明显升高免疫功能低下小鼠的碳廓清指数。结论: 双参苓颗粒对慢性肾功衰竭大鼠的高氮质血症及贫血状态有明显改善作用

对慢性肾衰具有一定的治疗作用

这种治疗作用与降低血液黏度、改善微循环、提高免疫功能有一定的联系。

Abstract

Objective: To investigate the effect of Shuangshenling Granules on treating chronic renal failure (CRF) and explore its mechanism to provide experimental basis for clinical application. Method: Rat model of CRF was induced by adenine and the effect of Shuangshenling Granules was tested. The effect on hemorheological indexes of blood stasis in rats

such as blood viscosity at low shear rate

was investigated; and the effects on microcirculatory disturbance and immunological function in mice were also tested. Result: Shuangshenling Granules could decrease the increased BUN and Crea induced by adenine in rat. The Granules could also improve the hemorheological indexes

microcirculation and immunological function in the experimental animals. Conclusion: Shuangshenling Granules have the function of delaying the progress of CRF which is related with hemorheological indexes

microcirculation and immunological function.

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