Optimal Extraction of Effective Constituents from Schisandra sphenanthera by Central Composite Design/Response Surface Methodology

XIAO Li; ZHANG Yun-hui

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Optimal Extraction of Effective Constituents from Schisandra sphenanthera by Central Composite Design/Response Surface Methodology

更新时间：2024-01-04

- Optimal Extraction of Effective Constituents from Schisandra sphenanthera by Central Composite Design/Response Surface Methodology
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 10, Pages: 22-25(2010)
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- Published：2010
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XIAO Li, ZHANG Yun-hui. Optimal Extraction of Effective Constituents from Schisandra sphenanthera by Central Composite Design/Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(10): 22-25.
DOI：

XIAO Li, ZHANG Yun-hui. Optimal Extraction of Effective Constituents from Schisandra sphenanthera by Central Composite Design/Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(10): 22-25. DOI：

摘要

目的: 采用星点设计-效应面法优化南五味子的提取工艺。方法: 以溶剂浓度

溶剂倍数及提取时间为自变量

五味子甲素提取率为因变量对自变量各水平进行多元线性回归和二项式拟合

用效应面法选择最佳提取工艺

进行预测分析

并将预测值与实验值进行比较。结果: 二项式拟合复相关系数较高

r为0.956 5

最佳提取工艺为62%的乙醇溶液回流提取2次

体积倍数为11.20倍

提取时间为3.00 h。提取率预测值与实验值偏差为0.22%。结论: 试验值与预测值吻合度高

星点设计-效应面法优化南五味子的提取工艺不仅方法简便

且预测性良好。

Abstract

Objective: To investigate the optimal extraction process of effective constituents from Schisandra sphenanthera by central composite design/response surface methodology. Method: Independent variables were ethanol concentration

reflux time and the volume ratio of material to solvent

dependent variable was extraction rate of schisandrin A. Linear and nolinear mathematic models were used to estimate the relationship between independent and dependent variables.Response surface methodology was used to optimize the process of extraction. Prediction was carried out through comparing the observed and predicted values. Result: It was showed that the regression coefficient of second-order quadratic model was as high as 0.956 5. The optimum conditions of extraction process were 62% ethanol

2.5 hours for reflux

11.20 fold solvent and 2 times for extraction.Bias between observed and predicted values was 1.22%. Conclusion: The observed values and predicted one are close to each other

which proved the optimum model is reasonable and predictive.

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Related Author

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LAN Qun

CHENG Yi

LI Zian

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Related Institution

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

Medical School， Lijiang Culture and Tourism College

Key Laboratory of Modern Preparation of Traditional Chinese Medicine （TCM），Ministry of Education，Jiangxi University of Chinese Medicine

Chengdu University of TCM

Medical School of Lijiang Culture and Tourism College

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