Rat Intestine Absorption Characteristics Study on Andrographolide with Isolated Everted Intestine Model

ZHANG Ying-feng; LI Yu-jie; Yang Qing; WENG Xiao-gang; DONG Yu; ZHU Xiao-xin

您当前的位置：

首页 >

文章列表页 >

Rat Intestine Absorption Characteristics Study on Andrographolide with Isolated Everted Intestine Model

更新时间：2024-01-04

- Rat Intestine Absorption Characteristics Study on Andrographolide with Isolated Everted Intestine Model
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 9, Pages: 107-110(2010)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2010
- 稿件说明：
移动端阅览
ZHANG Ying-feng, LI Yu-jie, Yang Qing, et al. Rat Intestine Absorption Characteristics Study on Andrographolide with Isolated Everted Intestine Model[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(9): 107-110.
DOI：

ZHANG Ying-feng, LI Yu-jie, Yang Qing, et al. Rat Intestine Absorption Characteristics Study on Andrographolide with Isolated Everted Intestine Model[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(9): 107-110. DOI：

摘要

目的 :考察穿心莲内酯的肠吸收特性。方法 :采用离体外翻肠囊模型研究穿心莲内酯在不同肠段、不同浓度下的肠吸收特性

采用HPLC\|UVD测定样品浓度

计算吸收速率常数(Ka)。结果 :随着药液中穿心莲内酯质量浓度上升

肠吸收速率常数呈线性增加;各个肠段的吸收速率均无显著性差异。结论 :穿心莲内酯在小肠内不存在特殊的"吸收窗"

在小肠中均为被动扩散吸收。

Abstract

Objective: To study the intestine absorption of andrographolide. Method: The isolated everted intestine model was used to study the absorption in different regions of rat intestine(duodenum

jejunum

ileum

colon). The samples were collected at different time and determined with HPLC in combination with ultraviolet detector. Result: The intestine absorption rate constant increased along with andrographolide concentration. The absorption rate had no significant difference between different regions of intestines and different andrographolide concentration. Conclusion: The absorption of andrographolide showed passive diffusion process and didn’t contain a special absorption window.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Pharmacological Effect and Mechanism of Andrographolide： A Review

HPLC Determination of Andrographolide and Dehyandrographolide in Fukeqianjin Capsules

Determination of Andrographolide in Resin Complexes of Andrographolide Ion-exchange Resin by HPLC

Research on in vitro Dissolution of Chuanxinlian Dropping Pills

Related Author

Hui-zhen QIN

Si LIN

Ling-yu DENG

Feng-feng XIE

Miao ZHANG

Hua ZHU

Long CHEN

GUO Yan-rong

Related Institution

Guangxi University of Chinese Medicine

Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine，Guangxi University of Chinese Medicine

Guangdong Province Municipal Institute of Traditional Chinese Medicine

Guangzhou University of Chinese Medicine

fong Pharmaceutical Corporation,Foshan

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰