The Analgesic Effect of Total Saponins of Psammosilene Tunicoids and its Suppression of c-fos Gene Expression in Adjuvant-induced Arthritis Rats
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The Analgesic Effect of Total Saponins of Psammosilene Tunicoids and its Suppression of c-fos Gene Expression in Adjuvant-induced Arthritis Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 3, Pages: 94-96(2010)
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Published:2010
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WANG Xue-yong, ZHANG Yuan, XU Jian-yang, et al. The Analgesic Effect of Total Saponins of Psammosilene Tunicoids and its Suppression of c-fos Gene Expression in Adjuvant-induced Arthritis Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(3): 94-96.
DOI:
WANG Xue-yong, ZHANG Yuan, XU Jian-yang, et al. The Analgesic Effect of Total Saponins of Psammosilene Tunicoids and its Suppression of c-fos Gene Expression in Adjuvant-induced Arthritis Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(3): 94-96.DOI:
The Analgesic Effect of Total Saponins of Psammosilene Tunicoids and its Suppression of c-fos Gene Expression in Adjuvant-induced Arthritis Rats
Objective: To investigate the analgesic effect and possible mechanism of total saponins of Psammosilene tunicoids (TSPT) for further reveal the mechanism of its antiarthritic effects. Methods: The method of hot plate was used to value the primary analgesic effect of TSPT and the c-fos gene expression was investigated by immunohistochemical method in tissues from adjuvant-induced arthritis(AA) rats. Results : TSPT showed obvious analgesic effects and when administration dose reaching 10 mg/kg
this effect approached alidine and surpassed the positive control of Fengshinin injection. Further more
TSPT could obviously suppress the c-fos gene expression both in center and periphery tissues in adjuvant-induced arthritis rats. Conclusion: TSPT has good analgesic effects and this effect might closely relate to c-fos gene expression both in center and periphery tissues in AA rats. This study would help to further investigate the possible mechanism of anti-rheumatoid arthritis for TSPT.