Pharmacokinetics Study on Sinomenine Hydrochloride in Rats with Administration route of Intramscular Injection by Using Microdialysis Method
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Pharmacokinetics Study on Sinomenine Hydrochloride in Rats with Administration route of Intramscular Injection by Using Microdialysis Method
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 8, Pages: 109-112(2010)
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Published:2010
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ZHANG Ying-feng, WANG Li-sheng, ZHOU Li-ling. Pharmacokinetics Study on Sinomenine Hydrochloride in Rats with Administration route of Intramscular Injection by Using Microdialysis Method[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(8): 109-112.
DOI:
ZHANG Ying-feng, WANG Li-sheng, ZHOU Li-ling. Pharmacokinetics Study on Sinomenine Hydrochloride in Rats with Administration route of Intramscular Injection by Using Microdialysis Method[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(8): 109-112.DOI:
Pharmacokinetics Study on Sinomenine Hydrochloride in Rats with Administration route of Intramscular Injection by Using Microdialysis Method
Objective: To explore the pharmacokinetics of sinomenine hydrochloride by using microdialysis method. Method: The microdialysis probe was introduced to right ventricle of rats as sampling tools for real-time and in vivo collecting samples after intramscular injection. The dialysate samples were determined by HPLC. After the dialysate concentration was calibrated
the blood-drug concentration was fitted with compartment and noncompartment model. Result: The results shows that physiological disposition of Sinomenine Hydrochloride was fitted to first order rate and open one-compartment model. The main pharmcokinetics parameters were as following: Cmax 3.127 mg·L-1
Tmax 101 min
MRT 191 min. Conclusion: The pharmacokinetics characteristics of Sinomenine Hydrochloride was collected by using microdialysis method which could been selected as study tool.
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Related Institution
School of Life Sciences,Beijing University of Chinese Medicine
School of Pharmacy,Shanghai University of Traditional Chinese Medicine
School of Graduate Studies,Tianjin University of Traditional Chinese Medicine(TCM)
The Second Affiliated Hospital of Tianjin University of TCM
First Teaching Hospital of Tianjin University of TCM