Effect of Ginger ( Roscoe) Oleoresin on Central Nervous System in Mice

JIANG Su-zhen; ZHOU Ting-ting

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Effect of Ginger ( Roscoe) Oleoresin on Central Nervous System in Mice

更新时间：2024-01-04

- Effect of Ginger ( Roscoe) Oleoresin on Central Nervous System in Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 7, Pages: 180-182(2010)
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- Published：2010
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JIANG Su-zhen, ZHOU Ting-ting. Effect of Ginger ( Roscoe) Oleoresin on Central Nervous System in Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(7): 180-182.
DOI：

JIANG Su-zhen, ZHOU Ting-ting. Effect of Ginger ( Roscoe) Oleoresin on Central Nervous System in Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(7): 180-182. DOI：

摘要

目的 :研究姜油对中枢神经系统的药理作用。方法 :采用小鼠自主活动法、延长戊巴比妥钠睡眠时间法、抗硝酸士的宁致惊厥试验法及醋酸诱导扭体反应和热板致痛试验法

观察姜油的镇静催眠、抗惊厥和镇痛作用。结果 :姜油能明显减少小鼠自发活动

延长戊巴比妥钠阈剂量睡眠时间

延长小鼠发生惊厥的潜伏期

大剂量能减少醋酸致小鼠扭体反应次数及抑制热板引起的疼痛。结论 :姜油具有显著的中枢抑制作用。

Abstract

Objective: To investigate the pharmacological action of ginger (Zingiber officinale Roscoe) oleoresin on central nervous system (CNS). Method: : After i.g. administration of ginger oleoresin upon mice

the spontaneous activity of mice was determined

latency and sleeping time induced by pentobarbitol were measured

strychinine-induced convulsion was observed

acetic acid-induced writhing and hot plate-induced pain were tested. Results: Ginger oleoresin could significantly reduced mice locomotor activity

prolonged pentobarbital-induced sleep time of mice

delayed latency of convulsion induced by strychnine

reduced the number of writhing and stretching induced by the acetic acid and delayed latency of reaction to the thermal stimulus. Conclusion: Ginger oleoresin has significant inhibitory effect on CNS.

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Related Institution

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School of Pharmacy，Xinxiang Medical University

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