The Experimental Study on Regeneration of Rat Common Peroneal Nerve Promoted by Buyang Huanwu Decoction

MEI Xiao-yun; ZHOU Lan; WU Hao-xin; SUN Hua-lin; XIE Hui; ZHAO Zong-bo

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The Experimental Study on Regeneration of Rat Common Peroneal Nerve Promoted by Buyang Huanwu Decoction

更新时间：2024-09-23

- The Experimental Study on Regeneration of Rat Common Peroneal Nerve Promoted by Buyang Huanwu Decoction
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 5, Pages: 114-117(2010)
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- Published：2010
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MEI Xiao-yun, ZHOU Lan, WU Hao-xin, et al. The Experimental Study on Regeneration of Rat Common Peroneal Nerve Promoted by Buyang Huanwu Decoction[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 114-117.
DOI：

MEI Xiao-yun, ZHOU Lan, WU Hao-xin, et al. The Experimental Study on Regeneration of Rat Common Peroneal Nerve Promoted by Buyang Huanwu Decoction[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 114-117. DOI：

摘要

目的 :研究补阳还五汤(BYHWD)促进大鼠夹伤腓总神经再生的作用。方法 :雄性SPF级SD大鼠60只

随机分为6组: BYHWD 高、中、低剂量组(剂量分别为25.92

12.96

6.48 g生药/kg)、弥可保组(剂量为625 μg/kg)、模型组、假手术组。采用大鼠腓总神经5 mm夹伤模型后

每日ig给药。术后18 d行电生理检测

测定复合肌动作电位;组织形态学分析

测定再生有髓神经纤维数、髓鞘厚度

观察BYHWD对大鼠夹伤腓总神经的再生作用。结果 :与模型组比

BYHWD高、中剂量组复合肌动作电位波幅、再生有髓神经纤维计数、髓鞘厚度均显著增高

有显著性差异。结论 :BYHWD有利于轴突生长和髓鞘形成

可以促进大鼠夹伤神经再生。

Abstract

Objective: To study the repairing effects of Buyang Huanwu Decoction(BYHWD) on rat common peroneal nerve after peripheral nerve injury. Method : Common peroneal nerve injury induced by clamp was established for sixty Sprague-Dawley rats

then they were randomly divided into 6 groups for daily intragastric administration of drugs: BYHWD high-dose (25.92 g/kg)

BYHWD medium-dose (12.96 g/kg)

BYHWD low-dose (6.48 g/kg)

mecobalamin (625 μg/kg) as the positive control

normal saline for model group and normal saline for the sham operation group. The drug administration lasted for 18 days. Electrophysiology was performed 18 days after operation to determine the compound muscle action potentials (CMAPs). The number of regenerated myelinated nerve fibers

thickness of myelin sheath and cross sectional area of tibial muscle were evaluated by histomorphology. Result : Amplitude of CMAP

the number of regenerated myelinated nerve fibers and thickness of myelin sheath in BYHWD high-dose and medium-dose group were all increased significantly compared with the model group. Conclusion : BYHWD contributes to axon growth and myelination reformation

thus promotes peripheral nerve regeneration in rats.

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Related Author

MEI Xiao-yun1

ZHOU Lan1

WU Hao-xin1

SUN Hua-lin2

XIE Hui1

ZHAO Zong-bo2

Si-cheng YAO

Xian-de MA

Related Institution

Nanjing University of Traditional Chinese Medicine

Jiangsu Key Laboratory of Neuroregeneration,Nantong University

Liaoning University of Traditional Chinese Medicine（TCM）

The Affiliated Hospital of Liaoning University of TCM

Shenyang Orthopaedic Hospital

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