The Experimental Study on the mRNA Expression of CYP11B2 in Rat with Kidney Deficiency and Diuresis Induced by Adenine
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The Experimental Study on the mRNA Expression of CYP11B2 in Rat with Kidney Deficiency and Diuresis Induced by Adenine
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 2, Pages: 64-67(2010)
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Published:2010
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LI Shu-wen, WU Qing-he, HUANG Ping, et al. The Experimental Study on the mRNA Expression of CYP11B2 in Rat with Kidney Deficiency and Diuresis Induced by Adenine[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(2): 64-67.
DOI:
LI Shu-wen, WU Qing-he, HUANG Ping, et al. The Experimental Study on the mRNA Expression of CYP11B2 in Rat with Kidney Deficiency and Diuresis Induced by Adenine[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(2): 64-67.DOI:
The Experimental Study on the mRNA Expression of CYP11B2 in Rat with Kidney Deficiency and Diuresis Induced by Adenine
Objective: To explore the mechanism for kidney deficiency and diuresis by studying the action of adenine to ALD synthase. Methods: The contents of Cort
ALD in blood were determined and the mRNA expression of CYP11B2 was evaluated with ELISA and RT-PCR in model group and control group. Results: Compared with control group
adenine could remarkedly decrease the contents of Cort
ALD in rat blood; and downregulate the mRNA expression of CYP11B2. Conclusion: Adenine can decrease the contents of Cort
ALD in blood and downregulate the mRNA expression of CYP11B2 in rats. It can decrease the synthesis of ALD by adjusting the ALD synthase. The results may expound the mechanism of kidney deficiency and diuresis induced by adenine from the angle of ALD synthase approach.
The Experimental Study on the mRNA Expression of CYP11B2 in Rat with Kidney Deficiency and Diuresis Induced by Adenine
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Related Author
LI Shu-wen~
吴清和
黄萍
操红缨
GUO Dengzhou
LI Wanzhe
JIN Peipei
ZHANG Yuanyuan
Related Institution
1*),WU Qing-he~2,HUANG Ping~2,CAO Hong-ying~2
广州中医药大学中药学院
Graduate School, Hebei University of Chinese Medicine
The First Affiliated Hospital of Hebei University of Chinese Medicine,Hebei Provincial Hospital of Traditional Chinese Medicine
Affiliated Hospital of Hebei University of Chinese Medicine/Hebei Provincial Hospital of Traditional Chinese Medicine