Research on HPLC Fingerprint of Tongsaimai Pellet

LI Wei-dong; CAI Bao-chang; DI Liu-qing

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Research on HPLC Fingerprint of Tongsaimai Pellet

更新时间：2024-01-04

- Research on HPLC Fingerprint of Tongsaimai Pellet
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 3, Pages: 16-19(2010)
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- Published：2010
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LI Wei-dong, CAI Bao-chang, DI Liu-qing. Research on HPLC Fingerprint of Tongsaimai Pellet[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(3): 16-19.
DOI：

LI Wei-dong, CAI Bao-chang, DI Liu-qing. Research on HPLC Fingerprint of Tongsaimai Pellet[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(3): 16-19. DOI：

摘要

目的 :通过通塞脉微丸指纹图谱的研究

建立该制剂稳定、可重复的质量控制手段。方法 :以Zorbax 80A Extend-C18(250 mm×4.6 mm

5 μm)为色谱柱

流动相为乙腈-0.1%磷酸溶剂系统

线形梯度洗脱

检测波长为276 nm

柱温30 ℃;采用指纹图谱相似度软件进行数据分析。结果 :建立了通塞脉微丸的HPLC对照指纹图谱

标示了21个共有色谱峰

通过与单味药及相应阴性制剂的比较确认了这21个色谱峰的归属;10批样品的色谱指纹图谱的整体相似度在0.984以上。结论 :通塞脉微丸HPLC指纹图谱的建立

对有效控制通塞脉微丸成品制剂的质量具有重要意义。

Abstract

Objective: To establish the HPLC fingerprint of Tongsaimai pellet. Method :The separation was performed on Zorbax 80A Extend-C18(250 mm×4.6 mm

5 μm)column with a mobile phase consisting of acetonitrile water with 0.1% phosphoric acid by gradient elution mode at the flow rate of 0.7 mL·min-1. The detecti wavelength was at 276 nm.The column temperature was at 30 ℃

the data were processed by fingerprint similarity evaluation software. Results: A standard HPLC fingerprint for Tongsaimai pellet with 21 common peaks was established.The similarity of 10 batches of Tongsaimai pellet was not lower than 0.984

The adscription of 21 common peaks was by comparing single herb or negative preparation with Tongsaimai pellet. Conclusion : This method can be used for quality control of Tongsaimai pellet.

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Related Institution

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