Influence of Yifei Huoxue Particles on Pulmonary Artery Pressure in Chronic Pulmonary Heart Disease in Rabbits Evaluated by Color Doppler Flow Imaging

ZHAI Hua-qiang; HE Sheng; YUAN Yuan; SHEN Yan-hua; OU Ming

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Influence of Yifei Huoxue Particles on Pulmonary Artery Pressure in Chronic Pulmonary Heart Disease in Rabbits Evaluated by Color Doppler Flow Imaging

更新时间：2024-01-04

- Influence of Yifei Huoxue Particles on Pulmonary Artery Pressure in Chronic Pulmonary Heart Disease in Rabbits Evaluated by Color Doppler Flow Imaging
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 10, Pages: 113-115(2010)
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- Published：2010
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ZHAI Hua-qiang, HE Sheng, YUAN Yuan, et al. Influence of Yifei Huoxue Particles on Pulmonary Artery Pressure in Chronic Pulmonary Heart Disease in Rabbits Evaluated by Color Doppler Flow Imaging[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(10): 113-115.
DOI：

ZHAI Hua-qiang, HE Sheng, YUAN Yuan, et al. Influence of Yifei Huoxue Particles on Pulmonary Artery Pressure in Chronic Pulmonary Heart Disease in Rabbits Evaluated by Color Doppler Flow Imaging[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(10): 113-115. DOI：

摘要

目的 :观察益肺活血颗粒对慢性肺源性心脏病(CPHD)家兔肺动脉压力的影响

探讨其改善肺动脉高压的作用机制。方法 :采用0.7%FeCl3溶液耳缘静脉注射造模方法建立CPHD家兔模型

随机设立正常组、模型组、卡托普利组及益肺活血颗粒组。彩色多普勒超声检测各组家兔肺动脉内径、右室流出道宽度、右室前壁厚度、右室内径、肺动脉流速、三尖瓣流速以及观察是否有反流。结果 :模型组与正常组比较

42d有显著性差异(P＜0.01);62d

益肺活血颗粒组与模型组比较

在右室内径、右室流出道、三尖瓣流速方面比较差异有统计学意义(P＜0.05)。结论 :益肺活血颗粒能缩小右室内径、降低右室流出道、减慢三尖瓣流速

改善CPHD家兔肺动脉压力。

Abstract

Objective: To study the influence of Yifei Huoxue Particles (YFHX) on pulmonary hypertension pathology in the chronic pulmonary heart disease (CPHD) in rabbits. Method: A total of 12 rabbits were randomly divided into 4 groups (normal group

model group

the captopril group

YFHX group)

each group 3

the rabbits in model group

the captopril group and YFHX group were modeled using 0.7% FeCl3 by ear vein injection. A total of 42 days

the rabbits in the captopril group and YFHX group were given captopril and YFHX accordingly. Then

a total of 20 days

pulmonary vascular injury was observed and compared. Result: Compared with the normal group

the model group showed structural changes in the heart in pulmonary artery diameter

right ventricular outflow tract

right ventricular front wall thickness and right ventricular track. The modeled rabbits showed significant difference compared with their own situation at 0 d and 42 d (P＜0.01)

YPHX treatment group are different with the model group for the indicators: Right ventricular outflow tract and tricuspid velocity (P＜0.05). Conclusion: YFHX can treat the model of CPHD caused by FeCl3 in rabbits

by reducing the right ventricular diameter and the right ventricular outflow tract and slowing down the tricuspid velocity.

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