Review on Interaction between Herb Metabolism and Cytochrome P450

WENG Xiao-gang; ZHU Xiao-xin; LIANG Ri-xin; Yang Qing; LI Yu-jie; WANG Yi-wei; LIU Xiao-ni; HAN Xiao

您当前的位置：

首页 >

文章列表页 >

Review on Interaction between Herb Metabolism and Cytochrome P450

更新时间：2024-01-04

- Review on Interaction between Herb Metabolism and Cytochrome P450
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 15, Issue 12, Pages: 104-108(2009)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2009
- 稿件说明：
移动端阅览
WENG Xiao-gang, ZHU Xiao-xin, LIANG Ri-xin, et al. Review on Interaction between Herb Metabolism and Cytochrome P450[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(12): 104-108.
DOI：

WENG Xiao-gang, ZHU Xiao-xin, LIANG Ri-xin, et al. Review on Interaction between Herb Metabolism and Cytochrome P450[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(12): 104-108. DOI：

摘要

目的:阐述中草药代谢与细胞色素P450酶(CYP450)的关系。方法:查阅近年来国内外相关文献100余篇

从CYP450概述、CYP450研究方法、代谢性相互作用以及中草药-药物相互作用与CYP450之间关系等方面进行文献归纳。结果:CYP450研究方法主要包括体外细胞、亚细胞水平研究及体内研究

CYP450酶活性改变是代谢性相互作用的主要原因

中草药复杂成分对CYP450酶活性影响较大。结论:CYP450在药物代谢中起重要作用

由中草药引起药物相互作用屡的原因大多缘于中草药影响了机体CYP450活性或机体CYP450蛋白表达

导致由CYP450参与代谢的其它药物在机体内代谢特征的改变

引发不良药物反应。

Abstract

Objective:To outlines the interaction between herbs metabolism and CYP450.Methods:Refer to more than 100 piece of literatures about CYP450 and sum up the article from conception of CYP450

study methods of CYP450

metabolism interaction and herbs metabolism.Results:study methods of CYP450 include methods in vitro and in vivo

and alteration in enzymic activity of CYP450 is reason of metabolism interaction.Conclusions:CYP450 plays an important role in drug metabolism;herbs have complicated ingredients and are reported to revoke some drug interaction often.The reason why drug interaction are caused by herbs is because these herbs affect activity or protein expression of CYP450 in organism and result in alteration of metabolism involved CYP450 of drugs thus to cause adverse drug reaction.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Attenuation Mechanism of Aconti Lateralis Radix Praeparata Combined with Glycyrrhizae Radix et Rhizoma Based on Heart CYP450 Isozymes

Effect of Inula cappa on CYP450 Enzyme in Rats by Cocktail Probe Drugs

Review of Chinese Herbal Medicine of Influencing on Cytochrome p450 System

Effect of Salviae Miltiorrhizae Radix et Rhizoma in Shenxiong Glucose Injectionon Cytochrome P450 in Mice

Inhibition of Baicalin on Activity of Cytochrome P450 Enzyme in Rat and Human Liver Microsomes

Related Author

Guang-ping ZHANG

Meng MA

Ping SU

Yi-fei YANG

Teng-fei CHEN

Zu-guang YE

Han LI

Chun WANG

Related Institution

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences

State Key Laboratory of Functions and Applications of Medicinal Plants, Provincial Key Laboratory of Pharmaceutics in Guizhou Province, Engineering Research Center for Development and Application of Ethnic Medicine and Traditional Chinese Medicine, Ministry of Education, School of Pharmaceutical Sciences, Guizhou Medical University

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰