Protective Effects of Water Extract of Rhizoma Coptidis and Fructus Evodiae on Ethanol-induced Rat Gastric Lesions

YU Xiao; WU Da-zheng

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Protective Effects of Water Extract of Rhizoma Coptidis and Fructus Evodiae on Ethanol-induced Rat Gastric Lesions

更新时间：2024-09-23

- Protective Effects of Water Extract of Rhizoma Coptidis and Fructus Evodiae on Ethanol-induced Rat Gastric Lesions
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 2, Pages: 60-64(2010)
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- Published：2010
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YU Xiao, WU Da-zheng. Protective Effects of Water Extract of Rhizoma Coptidis and Fructus Evodiae on Ethanol-induced Rat Gastric Lesions[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(2): 60-64.
DOI：

YU Xiao, WU Da-zheng. Protective Effects of Water Extract of Rhizoma Coptidis and Fructus Evodiae on Ethanol-induced Rat Gastric Lesions[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(2): 60-64. DOI：

摘要

目的: 研究不同配比黄连吴茱萸药对水提物对乙醇致大鼠急性胃损伤的保护作用及其可能的机制。方法: 大鼠经腹腔注射6 ∶1

6 ∶6

1 ∶6 3种不同配比的黄连吴茱萸药对水提物后

通过形态测量法测定胃损伤程度;用ex-vivo chamber法测定50%乙醇造成胃损伤前后的胃电压(PD)变化及灌流液pH值和H+含量。结果: 与对照组比较

黄连吴茱萸1 ∶6药对水提物显著降低胃损伤指数

加快PD的恢复

降低胃灌流液pH值和增加H+含量;黄连吴茱萸6 ∶6降低胃损伤指数。结论: 黄连吴茱萸1 ∶6水提物对50%乙醇造成的大鼠急性胃损伤具有较好的保护作用

显著优于黄连吴茱萸6 ∶1和6 ∶6;其机制可能与抑制酸反渗

增强胃黏膜屏障功能有关

提示吴茱萸在介导胃黏膜保护作用中担当着重要的作用。

Abstract

Objective: To investigate the protective effects of water extract of Coptis chinensis and Evodia rutaecarpa on ethanol-induced acute gastric lesions in rats. Methods: In this study

animals were intraperitoneally pretreated with vehicle (normal saline) or Coptis chinensis and Evodia rutaecarpa water extract at 1050 (6 ∶1)

1800 (6 ∶6)

1050 (1 ∶6) mg·kg-1. Three hours later

gastric lesions were induced by topical application of 50% ethanol for 10 min. The length index of gastric lesions were determined by morphological analysis in a gastric intubatton model. The rat gastric transmucosal potential difference (PD) was recorded continuously by ex-vivo chamber technique. The pH value and H+ content of gastric perfusate were mesured by pH meter and pH-stat technique

respectively. Results: Compared with control

Coptis chinensis and Evodia rutaecarpa water extract (1 ∶6) accelerated PD recovery and reduced gastric morphologic lesions. Coptis chinensis and Evodia rutaecarpa water extract (1 ∶6) elevated H+ content and reduced pH value. Coptis chinensis and Evodia rutaecarpa water extract (6 ∶6) reduced gastric morphologic lesions. Conclusions: Coptis chinensis and E. rutaecarpa water extract (1 ∶6) showed effectively protective actions on ethanol-induced acute gastric lesions in rats

and the gastroprotective mechanisms maybe due to the strengthening action on gastric mucosal lining and the inhibition of acid backdiffusion. This investigation also indicated that E. rutaecarpa maybe have a critical role in gastroprotective effect.

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Related Institution

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上海市复方中药重点实验室

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Key Laboratory of Dunhuang Medicine， Ministry of Education， Gansu University of Chinese Medicine

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