Objective: To investigate the effects of various coating parameters on release of a pH-dependent sustained release tablet of tegaserod maleate. Methods : Coating parameters

such as coating temperature

rotation speed of coating pan

spray pressure

spray rate

spray distance and coating solution temperature

were evaluated and the release was in vestigated by similarity factor. Results : Coating temperature significantly affected drug release while other parameters hed on obvious influence on drug release. Conclusion : Optimal coating parameters were as followed: coating temperature of 30 ℃

rotation speed of 25 rpm

spray pressure of 0.6 MPa

spray rate of 5 mL·min-1

spray distance of 17 cm and coating solution temperature of 30 ℃.