Difference of Passive Cutaneous Anaphylaxis between SD and Wistar Rats

LI Xiu-fang; JIN Ruo-min; FU Sheng-guang; YAO Guang-tao; TAN Meng-hui

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Difference of Passive Cutaneous Anaphylaxis between SD and Wistar Rats

更新时间：2024-01-04

- Difference of Passive Cutaneous Anaphylaxis between SD and Wistar Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 10, Pages: 102-105(2010)
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- Published：2010
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LI Xiu-fang, JIN Ruo-min, FU Sheng-guang, et al. Difference of Passive Cutaneous Anaphylaxis between SD and Wistar Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(10): 102-105.
DOI：

LI Xiu-fang, JIN Ruo-min, FU Sheng-guang, et al. Difference of Passive Cutaneous Anaphylaxis between SD and Wistar Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(10): 102-105. DOI：

摘要

目的:比较SD

Wistar 2种品系大鼠对卵蛋白(OVA)、天花粉蛋白(TCS)诱导的被动皮肤过敏(passive cutaneous anaphylaxis

PCA)反应的差异性。方法:选用SD

Wistar 2种品系大鼠

以OVA

TCS为致敏原

PCA反应时出现蓝斑的直径及阳性反应率作为判别标准

进行大鼠同种或小鼠异种PCA试验

并考查佐剂的应用与否对试验结果产生影响。结果:大鼠同种PCA加或不加佐剂的TCS反应均为阳性

蓝斑直径大小SD大鼠＞Wistar大鼠;加入氢氧化铝凝胶佐剂可提高两品系大鼠对OVA的过敏反应阳性率

且Wistar大鼠的敏感性高于SD大鼠;小鼠异种PCA试验显示:耳廓皮内分别注射两种品系大鼠不加佐剂致敏的OVA抗血清时均呈阴性反应

注射SD大鼠天花粉蛋白抗血清后

呈阳性反应;分别注射加入佐剂致敏的OVA

TCS抗血清

则小鼠异种PCA反应均呈阳性。结论:2种品系大鼠对OVA

TCS的敏感性存在较大差异

SD大鼠对TCS较敏感

而Wistar大鼠对OVA的敏感性较强;加入佐剂可提高两种品系大鼠对OVA的过敏反应阳性率。

Abstract

Objective:To compare the different sensitivity passive cutaneous anaphylaxis(PCA) caused by OVA and TCS between Sprague Dawley(SD) and Wistar rats.Method: PCA was performed by using SD and Wistar rats

and xenogenic PCA by using KM mice.OVA and TCS were taken as allergens.The diameter of dermal evan’s blue spot and the positive reaction rate were measured to discriminate severity of PCA. Result: Homologous PCA revealed that after injecting with 0.9 mg/rat TCS with or without adjuvant

two rat strains showed positive reaction.According to the diameter evan’s blue spots

the degree of response was as follows: SD rat > Wistar rat.The allergic positive reaction rate of two rat strains would be improved by adding aluminium hydroxide into OVA(5 mg/rat)

and the sensitivity of OVA of Wistar rat was more than SD rat.Xenogeneic PCA showed that after auricular intradermally injecting with OVA antiserum without aluminium hydroxide of two different rat strains

the mice demonstrated negative reaction.But the positive reaction was showed by injecting with TCS antiserum without adjuvant of SD rat.The mice showed positive reaction after auricular intradermally injecting with OVA or TCS with adjuvant of two rat strains. Conclusion: There are differences in sensitivity of OVA and TCS between SD and Wistar rat strains

and SD rat is the more sensitive of TCS than Wistar rat.Otherwise

Wistar rat is more sensitive of OVA.The allergic positive reaction rate will be improved by adding aluminium hydroxide into OVA.

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Related Institution

School of Basic Medicine， Gansu University of Chinese Medicine

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