The Effect of Xiaoyao San and It's Splited Prescription on the Ability of Learning and Memory and Antioxidant of Alzheimer's Disease Model Mice
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The Effect of Xiaoyao San and It's Splited Prescription on the Ability of Learning and Memory and Antioxidant of Alzheimer's Disease Model Mice
Chinese Journal of Experimental Traditional Medical FormulaeVol. 15, Issue 10, Pages: 102-104(2009)
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Published:2009
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WU Hong-yan, WANG Hu-ping. The Effect of Xiaoyao San and It's Splited Prescription on the Ability of Learning and Memory and Antioxidant of Alzheimer's Disease Model Mice[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(10): 102-104.
DOI:
WU Hong-yan, WANG Hu-ping. The Effect of Xiaoyao San and It's Splited Prescription on the Ability of Learning and Memory and Antioxidant of Alzheimer's Disease Model Mice[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(10): 102-104.DOI:
The Effect of Xiaoyao San and It's Splited Prescription on the Ability of Learning and Memory and Antioxidant of Alzheimer's Disease Model Mice
Objective:To investigate the effect of Xiaoyao San and it's splited prescription on the ability of learning and memory
SOD in blood serum
MDA in brain tissue of Alzheimer's Disease(AD) model mice made by D-gal and discuss the function and mechanism that Xiaoyao San defend AD.Methods:Using inject D-gal to make AD model mice while cured by Quanfang group
Shugan Jianpi group
Shugan Yangxue group
Jianpi Yangxue group of Xiaoyao San for 42 days.In the 41st day
make training of ability of learning and memory
in the 42nd day
test ability of learning and memory
then
collect blood and brain tissue to mensurate SOD in blood serum
MDA in brain tissue.Results: Quanfang group
Shugan Jianpi group
Shugan Yangxue group
Jianpi Yangxue group of Xiaoyao San could improve ability of learning and memory and reduce the latency
but Quanfang group was the most obvious.Quanfang group
Shugan Jianpi group
Shugan Yangxue group
Jianpi Yangxue group of Xiaoyao San could increase SOD in blood serum and reduce MDA in brain tissue
but Quanfang group is the most obvious too.Conclusions:Xiaoyao San can amend the behavioral index of AD model mice and that may be relate to antioxidation.
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Related Institution
First People’s Hospital of Foshan
The R&D Center of Drug for Renal Diseases,Guangzhou Consun Pharmaceutical Co.,Ltd
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