Earliest Investigation on Application of Isolated Heart Perfusion Technique to Evaluate Bioactivity of Antianginal Chinese Medicine
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Earliest Investigation on Application of Isolated Heart Perfusion Technique to Evaluate Bioactivity of Antianginal Chinese Medicine
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 9, Pages: 66-69(2010)
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Published:2010
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KUANG Rong, ZHU She-min, NI Wei -fang, et al. Earliest Investigation on Application of Isolated Heart Perfusion Technique to Evaluate Bioactivity of Antianginal Chinese Medicine[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(9): 66-69.
DOI:
KUANG Rong, ZHU She-min, NI Wei -fang, et al. Earliest Investigation on Application of Isolated Heart Perfusion Technique to Evaluate Bioactivity of Antianginal Chinese Medicine[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(9): 66-69.DOI:
Earliest Investigation on Application of Isolated Heart Perfusion Technique to Evaluate Bioactivity of Antianginal Chinese Medicine
Objective: To investigate the application of isolated heart perfusion technique to evaluate the bioactivity of antianginal Chinese medicine. Method: Isolated guinea pig heart perfusion was performed with Langendorff method to measure the change in perfusion volume of coronary pre and after administrating the 5 antianginal chinese medicines such as Danshen Injection
Guanxinnin Injection
Xiangdan Injection
Danhong Injection and Danshen for Injection. Result : All 5 injections above could dilate the coronary and increase the perfusion volume
but there was discrepancy in the increase of perfusion volume at the same dose of different lot number from same injection. Conclusion : It may be possible that Langendorff isolated heart perfusion technique would become a good method for evaluating the bioactivity of antianginal Chinese medicine and deserves further probe.