Objective: To object the influence of a Chinese herbal compound granule with functions of cooling and promoting blood circulation on coagulation function and whole blood viscosity in rats with radiation-induced lung injury. Method: Ninety male wistar rats were randomly assigned to blank group

model group and treatment group with 30 rats in each group. The rats in model and treatment group were irradiated with 6 MV x-rays

25Gy/fraction in the right lung and were given saline or Chinese herbal compound granule accordingly. The rats in blank group were given saline without radiation. Ten rats in each group were sacrificed at the time of 7 d

30 d and 90 d after radiation. The tissue pathology was conducted;Whole blood viscosity and coagulation indexes were evaluated. Result: The rats in model group developed radiation pneumonitis and fibrosis. The pathological changes of radiation injury in treatment group were slighter than the model group. The rats in model group were in the high coagulation and viscosity state in 7 d

in the low coagulation and viscosity state in 30 d

in the low coagulation and high viscosity state in 90 d. The coagulation time in the treatment group was longer in 7 d

shorter in 30 d and 90 d;The whole blood viscosity was decreased in 7 d

increased in 30 d

decreased in 90 d. Conclusion: Blood coagulation function disorder and viscosity abnormality occurred in the radiation-induced lung injury. The herbal compound granule with functions of cooling and promoting blood circulation can make appropriate adjustment and reduce the radiation-induced lung injury.