Determination of Tetramethylpyrazine and Ferulic Acid in Kangxuanyun Granules by RP-HPLC

LI Wan-qing; FAN Jun-ting; LIU Yong; FAN Hua

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Determination of Tetramethylpyrazine and Ferulic Acid in Kangxuanyun Granules by RP-HPLC

更新时间：2024-09-23

- Determination of Tetramethylpyrazine and Ferulic Acid in Kangxuanyun Granules by RP-HPLC
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 6, Pages: 59-61(2010)
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- Published：2010
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LI Wan-qing, FAN Jun-ting, LIU Yong, et al. Determination of Tetramethylpyrazine and Ferulic Acid in Kangxuanyun Granules by RP-HPLC[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 59-61.
DOI：

LI Wan-qing, FAN Jun-ting, LIU Yong, et al. Determination of Tetramethylpyrazine and Ferulic Acid in Kangxuanyun Granules by RP-HPLC[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 59-61. DOI：

摘要

目的: 建立高效液相色谱法(HPLC)同时测定抗眩晕颗粒中盐酸川芎嗪和阿魏酸的含量。方法: 色谱柱为AGT C18(4.6 mm×250 mm

5 μm);流动相为甲醇-乙腈-1%冰乙酸(1 ∶1 ∶5);检测波长280 nm;流速0.8 mL ·min-1;柱温25 ℃。结果: 盐酸川芎嗪在0.002 4~6.900 0 μg线性良好

r=0.999 8;阿魏酸在2.040 0~58.650 0 μg线性良好

r=0.999 0;盐酸川芎嗪平均回收率98.75%

RSD 1.12%;阿魏酸平均回收率98.45%

RSD 0.62%。结论: 高效液相法可靠、准确

专属性强

重现性好

可用于该制剂质量控制。

Abstract

Objective: To determine the contents of tetramethylpyrazine and ferulic acid in Kangxuanyun Granule. Method: C18 Column was used with methanol acetonitrile for chromatography-1%acetic acid glacial(1 ∶1 ∶5) at a flow rate of 0.8 mL ·min-1. The detecting wavelength was set at 280 nm. Result: The content of ferulic acid and tetramethylpyrazine can be determined by HPLC. The linearity of tetramethylpyrazine was good in the range of 0.002 4~6.900 0 μg

r=0.999 8; The linearity of ferulic acid was good in the range of 2.040 0~58.650 0 μg

r=0.999 0. The average recovery of tetramethylpyrazine was 98.75%

RSD 1.12%

the average recovery of ferulic acid was 98.45%

RSD 0.63%. Conclusion: The method is simple reliable accurate and can be applied as the quantity control method of Kangxuanyun Granule.

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Related Author

LI Wan-qing

FAN Jun-ting

LIU Yong

FAN Hua

ZHANG Cui-ying1

LI Zhen-guo1

MA Xiao-feng2

XU Jin-ling1

Related Institution

Tianjin Nankai Hospital

Dept.of Pharmacy,General Hospital Group Oilfield Hospital of Daqing

Liaoning University of Traditional Chinese Medicine

Henan Hospital of Traditional Chinese Medicine

Henan College of Traditional Chinese Medicine

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