Optimization of Extraction Technology for Chaiqin Qinggan Formular with Multiple Components Evaluation

FU Ke; ZHANG Kun; YAN Guang-li

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Optimization of Extraction Technology for Chaiqin Qinggan Formular with Multiple Components Evaluation

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- Optimization of Extraction Technology for Chaiqin Qinggan Formular with Multiple Components Evaluation
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 6, (2010)
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- Published：2010
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FU Ke, ZHANG Kun, YAN Guang-li. Optimization of Extraction Technology for Chaiqin Qinggan Formular with Multiple Components Evaluation[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6).
DOI：

FU Ke, ZHANG Kun, YAN Guang-li. Optimization of Extraction Technology for Chaiqin Qinggan Formular with Multiple Components Evaluation[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6). DOI：

摘要

目的: 优化柴芩清肝方的提取工艺。方法: 建立柴芩清肝方中黄芩苷、甘草苷和芍药苷3种成分同时测定的HPLC方法。采用L9(34)正交设计法

以黄芩苷、甘草苷、芍药苷3种成分含量综合评分法进行数据分析

对柴芩清肝方的提取次数、提取时间和加水量3因素进行优化。结果: 3因素中只有提取次数有显著影响

最佳提取工艺为A3B1C3。结论: 多成分评价法优选柴芩清肝方提取工艺能较好地保证制剂的质量。

Abstract

Objective: To optimize the extraction technology of Chaiqin Qinggan Formular. Method: A HPLC method was established to simultaneously determine the contents of baicalin

paeoniflorin and glycyrrhizin in the extractions of Chaiqin Qinggan Formular. Based on the orthogonal design of L9(34) and the weighted method

three factors including the multiple water

decocting time

and extracting times were evaluated. Result: Significant effect was observed in extracting times. The best extraction process is A3B1C3. Conclusion: The extraction technology optimized with multiple components evaluation is reasonably practicable.

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Related Author

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Related Institution

Research Center for Differentiation and Development of Traditional Chinese Medicine （TCM） Basic Theory， Jiangxi Province Key Laboratory of TCM Etiopathogenisis， Jiangxi University of Chinese Medicine

The Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital

Fuwai Central China Cardiovascular Hospital/Henan Provincial People's Hospital

Henan University of Chinese Medicine

School of Pharmacy，Changchun University of Chinese Medicine

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