Protective Effect of Xingnaojing Emulsion on Hemorrhagic Shock and Septic Shock in Rabbits
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Protective Effect of Xingnaojing Emulsion on Hemorrhagic Shock and Septic Shock in Rabbits
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 1, Pages: 98-101(2010)
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Published:2010
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DONG Liu-yi, WEI Qian. Protective Effect of Xingnaojing Emulsion on Hemorrhagic Shock and Septic Shock in Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(1): 98-101.
DOI:
DONG Liu-yi, WEI Qian. Protective Effect of Xingnaojing Emulsion on Hemorrhagic Shock and Septic Shock in Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(1): 98-101.DOI:
Protective Effect of Xingnaojing Emulsion on Hemorrhagic Shock and Septic Shock in Rabbits
Objective: To observe the protective effect of Xingnaojing Emulsion (XNJE) on hemorrhagic shock and septic shock in rabbits. Methods: A rabbit model of hemorrhagic shock was established by bloodletting from femoral artery of rabbits; LPS of E.coli was injected to rabbits via vein to induce septic shock. The successful model rabbits were equally and randomly assigned into 5 groups: normal saline (NS) control group
low
middle and high dose of XNJE (25.7
51.4
102.75 mg·kg-1)group and positive control group (treated with Xingnaojing injection
51.4 mg·kg-1) (n=8 for each group). The antishock effect of XNJE was then observed. Results: In the hemorrhagic shock model
XNJE could obviously heighten the blood pressure
quicken the heart rate
inhibit the abnormal increase of MDA and enhance the activity of SOD in serum.Besides
in the septic shock model
XNJE could lower the death rate of rabbits
extend the survival time
heighten the blood pressure
inhibit the abnormal increase of MDA
lower the content of NO and enhance the activity of SOD in serum. Conclusion: XNJE exerts a protective effect on hemorrhagic shock and septic shock in rabbits
which could be related with the improvement of microcirculation and antioxidation.