Protective Effect of Weishu Powder on Experimental Acute Gastritis in Rat
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Protective Effect of Weishu Powder on Experimental Acute Gastritis in Rat
Chinese Journal of Experimental Traditional Medical FormulaeVol. 15, Issue 6, Pages: 47-49(2009)
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Published:2009
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LIN Xu-kai1, XIAO Yong1, HAN Jian2, et al. Protective Effect of Weishu Powder on Experimental Acute Gastritis in Rat[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(6): 47-49.
DOI:
LIN Xu-kai1, XIAO Yong1, HAN Jian2, et al. Protective Effect of Weishu Powder on Experimental Acute Gastritis in Rat[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(6): 47-49.DOI:
Protective Effect of Weishu Powder on Experimental Acute Gastritis in Rat
降低醋酸致小鼠发生扭体反应的次数(与空白组比较P<0.05或P<0.01);而陈香露白露片高、低剂量组与胃舒散同等剂量组的作用差异明显(P<0.05 or P<0.01)。结论:胃舒散对乙醇致胃粘膜损伤和水杨酸钠诱发的大鼠急性胃炎有明显的保护作用
并能显著抑制醋酸诱发的小鼠扭体反应次数
且胃舒散作用强于同剂量的陈香露白露片。
Abstract
Objective:To observe the protective effect of Weishu Powder (WP) on experimental acute gastritis in rat. Methods: fifty-six SD rats were randomized into normal group
model group
low-dose WP group
high-dose WP group
low-does Chen-xiang-lu-bai-lu tablet (Chen) group
high-dose Chen group and Cimetidine group. The rats in the above groups were fed with the corresponding drugs by gastric infusion for 3 days. The injury of stomach mucous membrane induced by alcohol and acute gastritis induced by sodium salicylate in rats were observed. Effect of WP on the count of somatic wrenching reaction induced by dilute acetic acid in mice were determined. Results: As compared with the model group
two dose groups of WP could depress the injury of stomach mucous membrane induced by alcohol and reduce the ulceration index of acute gastritis induce by sodium salicylate (P<0.05 or P<0.01)
also decreased the count of somatic wrenching reaction in mice. The different effects between WP and Chen in the same dose was significant (P<0.05 or P<0.01). Conclusion: WP possess markedly protective effect on the injury of stomach mucous membrane in rat
it also reduced the wrenching count in mice.The effect of WP was superior to Chen in the same dose.
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Related Institution
School of Basic Medicine, Gansu University of Chinese Medicine
Gansu Key Laboratory of Traditional Chinese Medicine Formula Innovation and Transformation
Key Laboratory of Dunhuang Medicine, Ministry of Education, Gansu University of Chinese Medicine
Hebei Province Hospital of Traditional Chinese Medicine