Objective: To prepare compound Danshen pellets. Method : The compound Danshen pellets were prepared by using a centrifugal granulator. The composition and process factors were optimized by adopting several indices such as sphericity of pellets

repose angle

bulk density and friability. Result : The optimal process parameters were as follows:the quality ratio of Borneol-β-Cyclodextrinclusion Complexes and MCC was 4 ∶3

binder solvent was 40% syrup

which including extractive. The rotating rate of plate was 200 r ·min-1

the blower rate was 8L ·min-1

the rate of air flow was 18 L ·min-1

the spray air pressure was 0.06 MPa

the rotating rate of spray solution pump was 12~17 r ·min-1 and the rotating rate of powder feed machine was 15~20 r ·min-1. The active components could release more than 85% in 15 minutes. Conclusion : Under the optimal conditions

the compound Danshen pellets prepared by using the centrifugal granulator have prefect shape and surface characteristics

the yield of target size pellets are more than 85%. The three index components could release fast and synchronically.