Study On Quality Standard For Chongshen Xiaoyan Capsule

XU Ai-li; BI Xiao-li; ZHANG Jian-jun; LUO Wen-hui

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Study On Quality Standard For Chongshen Xiaoyan Capsule

更新时间：2024-01-04

- Study On Quality Standard For Chongshen Xiaoyan Capsule
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 15, Issue 12, Pages: 13-15(2009)
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- Published：2009
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XU Ai-li, BI Xiao-li, ZHANG Jian-jun, et al. Study On Quality Standard For Chongshen Xiaoyan Capsule[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(12): 13-15.
DOI：

XU Ai-li, BI Xiao-li, ZHANG Jian-jun, et al. Study On Quality Standard For Chongshen Xiaoyan Capsule[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(12): 13-15. DOI：

摘要

目的:建立重参消炎胶囊的质量标准。方法:采用薄层色谱法对重参消炎胶囊中的重楼、当归、苦参进行定性鉴别;采用高效液相色谱法测定制剂中苦参碱的含量

色谱柱:NUCLEOSIL-NH2(4.6mm×250mm

5μm)柱;流动相:乙腈-无水乙醇-3%磷酸溶液(80∶10∶10);流速:1.0mL/min;柱温:25℃;检测波长为220nm。结果:重楼、当归、苦参特征斑点清晰

分离度好

阴性无干扰。苦参碱在0.4332～2.1660μg范围内呈良好的线性关系

r=0.99945

平均回收率为100.54%

RSD=1.85%。结论:所建立的方法简便准确

专属性、重复性好

可作为重参消炎胶囊的质量控制标准。

Abstract

Objective:To establish the quality standard for chongshen xiaoyan capsule.Methods:Rhizoma Paridis

Radix Angelicae Sinensis and Radix Sophorae Flavescentis were identified by TLC;The content of matrine was determined by HPLC in this preparation.NUCLEOSIL-NH2 column was used.The mobile phase was consisted of Acetonitrile-Ethanol-water wich 3% phosphoric acid(80∶10∶10).The flow rate was 1.0 mL·min-1 and column temperature was at 25 ℃.The detection wave length was at 220 nm.Results:The spots on TLC plates were clear without indeference in the blank reference.The linear range of matrine was 0.433 2～2.166 0 μg

r=0.999 45.The average recovery of matrine was 100.54% and RSD was 1.85%.Conclusion:The methods of identification and quantification is easy

accurate and reproducible.It can be used effectively for the quality control of this preparation.

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Related Author

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Related Institution

National Institutes for Food and Drug Control

School of TCM， Beijing University of Chinese Medicine

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National Engineering Laboratory for Quality Control Technology of Chinese Materia Medica， Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

Medicinal College， Guangxi University

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