The Significance of Expression of MMP-2 in the Vertebral Artery in Rabbits with Cervical Spondylosis and the Intervenient Effects of Compound Chuanji Pills
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The Significance of Expression of MMP-2 in the Vertebral Artery in Rabbits with Cervical Spondylosis and the Intervenient Effects of Compound Chuanji Pills
Chinese Journal of Experimental Traditional Medical FormulaeVol. 15, Issue 10, Pages: 75-77(2009)
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Published:2009
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SHOU Zhe-xing, SHEN Lin, XIONG Peng-cheng. The Significance of Expression of MMP-2 in the Vertebral Artery in Rabbits with Cervical Spondylosis and the Intervenient Effects of Compound Chuanji Pills[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(10): 75-77.
DOI:
SHOU Zhe-xing, SHEN Lin, XIONG Peng-cheng. The Significance of Expression of MMP-2 in the Vertebral Artery in Rabbits with Cervical Spondylosis and the Intervenient Effects of Compound Chuanji Pills[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(10): 75-77.DOI:
The Significance of Expression of MMP-2 in the Vertebral Artery in Rabbits with Cervical Spondylosis and the Intervenient Effects of Compound Chuanji Pills
Objective:To explore the significance of expression of MMP-2 in the vertebral artery and the intervenient effects of Compound Chuanji Pills on it.Methods: Forty rabbits were randomly divided into four groups: the normal group
the model group
the Jingfukang(JFK) Group and the Chuanji Pills(CJP)group.The method of injecting sclerosing agent was used to induce the vertebral artery type of cervical spondylosis in rabbits.Four weeks later
the model group
JFK group and CJP group were treated with sodium chloride
suspension of JFK or suspension of CJP respectivily by intragastric administration.After four weeks of therapy
the pulsatility index of the vertebral artery
the plasma viscosity
the blood viscosity and the expression of matrix metalloproteinase-2(MMP-2) in the vertebral artery were detected.Results: The pulsatility index
plasma viscosity
blood viscosity and expression of MMP-2 were significantly higher in the model group than that of normal group(P<0.05);compared with the normal group and the model group
the pulsatility index of the vertebral artery
plasma viscosity
blood viscosity and expression of MMP-2 decreased remarkably in the CJP group(P<0.05).Conclusion: One of the mechanism of CJP in treating of cervical spondylosis might partially inhibit the expression of MMP-2 in the vertebral artery.
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Effect of Modified Danggui Shaoyao San on MMP-2, ICAM-1, Emorheology and Inflammation in Patients with Chronic Pelvic Inflammatory Disease
Shujin Tongluo Granule Treatment 172 Cases of Cervical Spondylosis
Effect of Different Couplet Medicines from Yushen Granules on Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-2 in Mesangial Cell
Determination of Sinomenine in Human Plasma by HPLC-MS/MS and Pharmacokinetic Analysis of Qishe Pills in Human
Related Author
Meiying QIN
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Related Institution
The First Clinical Medical School, Guangzhou University of Chinese Medicine
Clinical School of Acupuncture and Rehabilitation, Guangzhou University of Chinese Medicine
Guangdong Peiying Vocational and Technical School
Henan Province Hospital of Traditional Chinese Medicine
The First Affiliated Hospital of Henan University of Chinese Medicine