Study on Constituents and Biological Activity of Volatile Oil From Seeds of  Maxin

XU Li-ying1; ZHANG Xiao-ping2; JIANG Ji-hong2

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Study on Constituents and Biological Activity of Volatile Oil From Seeds of Maxin

更新时间：2024-01-04

- Study on Constituents and Biological Activity of Volatile Oil From Seeds of Maxin
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 15, Issue 8, Pages: 38-42(2009)
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- Published：2009
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XU Li-ying1, ZHANG Xiao-ping2, JIANG Ji-hong2. Study on Constituents and Biological Activity of Volatile Oil From Seeds of Maxin[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(8): 38-42.
DOI：

XU Li-ying1, ZHANG Xiao-ping2, JIANG Ji-hong2. Study on Constituents and Biological Activity of Volatile Oil From Seeds of Maxin[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(8): 38-42. DOI：

摘要

目的:分析栝楼子挥发油成分并检测其生物活性。方法:采用水蒸汽蒸馏法提取

气相色谱-质谱联用法进行成分分析

并分别用测A值和MTT法检测其抑菌和细胞毒生物活性。结果∶从分离的挥发油化合物中

鉴定出42个化合物

占挥发油总相对含量的79.434%。挥发油对金黄色葡萄球菌、大肠杆菌有较好的抑制作用;对真菌红酵母有显著的抑制作用

在800μg·mL-1时抑制率达到90.91%;对肿瘤胃癌细胞株SGC-7901细胞也有显著的细胞毒活性

浓度为50μg·mL-1时

抑制率高达86.13%。结论:首次从挥发油的角度来研究栝楼的药理作用

其挥发油有抑菌活性和对胃癌细胞株SGC-7901细胞有很好的细胞毒活性。

Abstract

The volatile oil was extracted from the seeds of Trichosanthes kirilowii Maxin by steam distillation and its chemical components were analyzed by GC-MS technique.Forty-two compounds were separated and identified

which represented 79.434% of the total relative content of the volatile oil.The biological activity of the volatile oil was screened with A and MTT methods.The experiment results suggested that the volatile oil possessed antibacterial activity against Staphalococus aureus、Escherichia coli

and it could also obviously inhibit the growth of cultured Rhodotorula sp.with a inhibition rate of 90.91% at a concentration of 800 μg·mL-1 and stomach cancer cell line(SGC-7901) with a inhibition rate of 86.13% at a concentration of 50 μg·mL-1.

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Related Institution

Institute of Chinese Material Medica，China Academy of Chinese Medical Sciences

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