The Protection of Active Component Injection of Bge.and L.on Myocardial Ischemical Reperfusion Injury in Rats
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The Protection of Active Component Injection of Bge.and L.on Myocardial Ischemical Reperfusion Injury in Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 15, Issue 6, Pages: 37-40(2009)
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Published:2009
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ZHANG Lei1, LIU Jian-gang1, SHI Da-zhuo1, et al. The Protection of Active Component Injection of Bge.and L.on Myocardial Ischemical Reperfusion Injury in Rats[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(6): 37-40.
DOI:
ZHANG Lei1, LIU Jian-gang1, SHI Da-zhuo1, et al. The Protection of Active Component Injection of Bge.and L.on Myocardial Ischemical Reperfusion Injury in Rats[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(6): 37-40.DOI:
The Protection of Active Component Injection of Bge.and L.on Myocardial Ischemical Reperfusion Injury in Rats
Objective:To observe the effect of active component injection of Slauia miltiorrhiza Bge. and Carthamus tinctorius L. (salvianolic acid B and hydroxysafflor yellow A) on myocardial ischemical reperfusion injury in rats. Methods:Myocardial ischemical reperfusion injury model of SD rat was established by ligation of left anterior descending branch for 40 min
and then reperfusion for 120 min. Ten minutes later after coronary ligation
the active component was injected intravenously. The rats were divided into 6 groups (n=10
each group)
they were model group
sham operation group
Danhong injection group
low dose
moderate dose and large dose groups of active component injection of Slauia miltiorrhiza Bge.and Carthamus tinctorius L..The degree of myocardial infarction in rats was determined for every group after 2 h of reperfusion
the contents of cTnT and CK-MB were detected. ST-T change in ECG
TXB2
6-Keto-PGF1α and platelet aggregation in blood plasma were investigated.Results:Compared with model group
every group of active component injection of Slauia miltiorrhiza Bge.and Carthamus tinctorius L. can significantly lower the increase of cTnT and CK-MB in rats(P<0.01)
moderate dose and large dose groups can remarkably lower the maximum platelet aggregation and TXB2 in rats (P<0.01
P<0.01)
correct the unbalance of 6-Keto-PGF1α /TXB2
lower the ST-T extent of ECG in 30 min of reperfusion. Conclusion:Active component injection of Slauia miltiorrhiza Bge.and Carthamus tinctorius L.can lower platelet aggregation induced by reperfusion injury in rats
reduce the leakage of impaired myocardial creatase
inhibit the production of thromboxan
prevent the formation of thrombus
improve the myocardial microcirculation and ischemia.
Simultaneous Determination of Eight Active Components in Material Benchmark of Shentong Zhuyutang by HPLC-DAD Wavelength Switching
Determination of Hydroxysafflor Yellow A, Gallic Acid and Aristolochic Acid A in Wuwei Zhaxun Pill by HPLC
Optimization of Vacuum Extraction Process for
Simultaneous Determination of Hydroxysafflor Yellow A and Ferulic Acid in Xielongjiegu Powder by HPLC
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Related Institution
College Pharmacy, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province, Key Laboratory Breeding Base of Co-founded by Sichuan Province and Ministry of Science and Technology
Gansu Provincial Institute of Food and Drug Control,Gansu Province Traditional Chinese Medicine Quality and Safety Evaluation of Engineering Technology Research Center
Nanjing University of Traditional Chinese Medicine,Key Laboratory for Modern Research of Traditional Chinese Medical Formulae of Jiangsu