Objective:To study the effect of Shenqi Fuzheng Injection on the balance of Th1/Th2 in S 180-bearing mice with chemotherapy. Methods:45 of 57 tumor-bearing mice were given cyclophosphamide twice by intraperitoneal injection

and then randomly divided into four groups:the model group、the high dose group (8 g·kg-1)、the clinical equivalent dose group(4 g·kg-1) and the low dose group (2 g·kg-1) of Shenqi Fuzheng Injection. The model group and the 12 tumor-bearing mice without cyclophosphamide injection were given physiological saline by intraperitoneal injection once a day

while the others were given Shenqi Fuzheng Injection in the same way. 9 days later

the eyes and 0.5 mL blood were obtained before each mouse was sacrificed.The blood was for cytometric bead aray(CAB)test.The tumors were weighed

and the tumor index was calculated.Results:Shenqi Fuzheng Injection

in the clinical equivalent dose

could significantly depress the weights of tumors and the tumor indexes(P<0.01)

and elevate the contents of TNF-α and IL-2 (P<0.01～0.05) in S180-bearing mice with chemotherapy. Conclusion:In clinical equivalent dose(4 g·kg-1)

Shenqi Fuzheng Injection could make Th1 cells to be predominant to Th2 cells in S180-bearing Mice with chemotherapy.