Effects in Volatile Oil of San Ao Tang and its Serial Decoctions on Ovalbumin Induced Asthma Model in Guinea Pig
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Effects in Volatile Oil of San Ao Tang and its Serial Decoctions on Ovalbumin Induced Asthma Model in Guinea Pig
Chinese Journal of Experimental Traditional Medical FormulaeVol. 15, Issue 5, Pages: 35-38(2009)
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Published:2009
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FENG Li1, Xu Li1, FAN Xin-sheng2, et al. Effects in Volatile Oil of San Ao Tang and its Serial Decoctions on Ovalbumin Induced Asthma Model in Guinea Pig[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(5): 35-38.
DOI:
FENG Li1, Xu Li1, FAN Xin-sheng2, et al. Effects in Volatile Oil of San Ao Tang and its Serial Decoctions on Ovalbumin Induced Asthma Model in Guinea Pig[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(5): 35-38.DOI:
Effects in Volatile Oil of San Ao Tang and its Serial Decoctions on Ovalbumin Induced Asthma Model in Guinea Pig
Objective:By observed the effection in volatile oil of San Ao Tang and its Serial decoctions on ovalbumin induced asthma model in guinea pig
their action on asthma is preliminary compared. Methods:Guinea pigs were sensitized intraperitoneally with 10% ovalbumin(OVA). Two weeks after sensitization they were challenged with 1% OVA aerosol. The delitescence
scores on ethology
percentages of eosinophils(EOS) in bronchoalveolar lavage fluid(BALF)
levels of interleukin(IL)-4
IL-5 and interferon gamma(IFN-γ) in serum were detected by enzyme-linked immunoassay(ELISA). Results:Volatile oil of San Ao Tang DecoctionⅠand Ⅱcould improve the percentages of EOS in BALF
IL-4
5 and IFN-γ in serum
and scores of lung tissue pathology. Volatile oil of San Ao Tang Decoction Ⅲ can significantly improve the percentages of EOS in BALF and pathological scores of lung tissue(P<0.01). Volatile oil of San Ao Tang can improve the percentages of EOS in BALF
and IL-4
IFN-γ in serum. Conclusion:Volatile oil of San Ao Tang DecoctionⅠandⅡcould regulate the immune function of the body
in aspects of regulating the cytokines
suppressing the inflammation in respiratory
and may directly inhibit the role of tracheal smooth muscle spasm
reaching its role of suppression in asthma symptoms. Volatile oil of San Ao Tang Decoction Ⅲ has the significant effects in inhibiting the production and aggregation of the EOS in respiratory.