Research on Qingxianfang's Function on Anti-hepatic Fibrosis in Rats
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Research on Qingxianfang's Function on Anti-hepatic Fibrosis in Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 15, Issue 12, Pages: 75-77(2009)
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Published:2009
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ZHANG Lin-jun1, LIU Guang-hui1, HUANG Dong-hua1, et al. Research on Qingxianfang's Function on Anti-hepatic Fibrosis in Rats[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(12): 75-77.
DOI:
ZHANG Lin-jun1, LIU Guang-hui1, HUANG Dong-hua1, et al. Research on Qingxianfang's Function on Anti-hepatic Fibrosis in Rats[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(12): 75-77.DOI:
Research on Qingxianfang's Function on Anti-hepatic Fibrosis in Rats
Objective:To explore the therapeutic mechanism of Qingxianfang for anti-hepatic fibrosis.Method: Hepatic fibrosis of Wistar rat was established by injecting CCl4 and divided them into groups marked "model"
"Qingxianfang" and "colchicines".Another group of normal rat was used as "control".After eight weeks of treatment
an observation of hepatic fibrosis is carried on by using HE and Masson pigmentation
immunohistochemistry and detecting the expression of collagen type I
type Ⅲ.TGF-β1 mRNA expression in hepatic tissue was determined by RT-PCR.Result: The collagen type Ⅰ
type Ⅲ and the expression of TGF-β1 mRNA reduced significantly in treatment group.Conclusion: Qingxianfang is effective for easing the liver damage and hepatic fibrosis condition in rats.The mechanism may be relative to the restraining of TGF-β1 expression in the liver.
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