Effect of TAN YU TON ZHI Prescription on PON-1 Activity and Inflammatory Factor in Atherosclerosis Rabbits
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Effect of TAN YU TON ZHI Prescription on PON-1 Activity and Inflammatory Factor in Atherosclerosis Rabbits
Chinese Journal of Experimental Traditional Medical FormulaeVol. 15, Issue 8, Pages: 53-56(2009)
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Published:2009
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LI Lei, LIU Jian-xun, LI Xin-zhi, et al. Effect of TAN YU TON ZHI Prescription on PON-1 Activity and Inflammatory Factor in Atherosclerosis Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(8): 53-56.
DOI:
LI Lei, LIU Jian-xun, LI Xin-zhi, et al. Effect of TAN YU TON ZHI Prescription on PON-1 Activity and Inflammatory Factor in Atherosclerosis Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(8): 53-56.DOI:
Effect of TAN YU TON ZHI Prescription on PON-1 Activity and Inflammatory Factor in Atherosclerosis Rabbits
Objective:To investigate the effect of TAN YU TON ZHI(TYTZ) prescription on PON-1 activity and inflammatory factor in atherosclerosis(AS) rabbits.Methods:Rabbits were divided randomly into six groups: normal control group
AS model group
simvastatin group
TYTZ 5
2.5
1.25 g·kg-1 group.The animal model of AS was established with a combined method of aortic balloon-injury and high cholesterol feeding.Rabbits were administrated the drugs 4 weeks after surgery.8 weeks after drug administration
the levels of TC
TG
HDL-C
LDL-C
PON-1 activity
CRP and IL-6 were determined.Results:The levels of TC
LDL-C decreased significant in simvastatin and TYTZ 5 g·kg-1 group than those in model group.The PON-1 activity in TYTZ 5
2.5 g·kg-1 group were significant higher than model group.The levels of CRP and IL-6 significant decreased in TYTZ 5
2.5
1.25 g·kg-1 group than those in model group.Conclusions:TYTZ prescription suppresses the development of atherosclerosis by modulating blood lipid
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Related Institution
School of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM)
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Chengdu University of Traditional Chinese Medicine(TCM)