Objective To observe the pharmacodynamic effect of Compound Qingre Granules(QRKL) on acute drug-resistance bacterial infection in rabbit model.Methods Applying abdominal injection of ATCC700603

we created the acute drug-resistance bacterial infection of rabbit model and divided them into five groups: normal(A)

model(B)

QRKL+ Cefdinir Capsules(C)

Cefdinir Capsules(D) and QRKL(E).We observed and recorded rabbits' vital signs

hemogram

immune function and inflammatory mediators

etc.Patho-samples were obtained after being sacrificed.Results QRKL has the significantly pharmacodynamic effect of treating acute drug-resistance bacterial infection.There are more significant effect through integrating traditional Chinese medicine and antibiotic together.Conclusion QRKL can significantly improve the infected rabbits' general conditions

decrease plasma endotoxin level

and regulate cytokines of the acute drug-resistance bacteria infection

while raises nonspecific immunity so as to control the inflammatory reaction and tissue damage and lower the mortality.