Regulation Effect of SHI-re-bi Tablet on T Lymphocyte and Cytokine Network in the Adjuvant-induced Arthritis Rats
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Regulation Effect of SHI-re-bi Tablet on T Lymphocyte and Cytokine Network in the Adjuvant-induced Arthritis Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 15, Issue 10, Pages: 52-54(2009)
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Published:2009
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XIN Zeng-hui1, XIAO Dan1, GAN Li1, et al. Regulation Effect of SHI-re-bi Tablet on T Lymphocyte and Cytokine Network in the Adjuvant-induced Arthritis Rats[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(10): 52-54.
DOI:
XIN Zeng-hui1, XIAO Dan1, GAN Li1, et al. Regulation Effect of SHI-re-bi Tablet on T Lymphocyte and Cytokine Network in the Adjuvant-induced Arthritis Rats[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(10): 52-54.DOI:
Regulation Effect of SHI-re-bi Tablet on T Lymphocyte and Cytokine Network in the Adjuvant-induced Arthritis Rats
Objective: To observe the influence of Shi-re-bi Tablet on T lymphocyte and cytokine network in the adjuvant-induced arthritis SD rats.Methods: Induce the model of adjuvant arthritis in SD rats through the immunization of heat-killed Mycobacterium Tuberculosis H37RA(Mtb).Measure the level of TNF-α and T lymphocyte subsets in the experimental animal's peripheral blood by ELISA.At the same time
measure the level of IL-1β
IL-6
IL-10 and VEGF in the synovial tissues of ankle joint in the rheumatoid arthritis rats.Results: Compared with the model group
Shi-re-bi Tablet could raise the level of CD8+ T lymphocyte(P<0.05) and reduce the ratio of CD4+/CD8+(P<0.05)
proinflammatory TNF-α
IL-1β and IL-6(P<0.01)
at the same time
the content of VEGF is reduced(P<0.01) and the level of anti-inflammatory IL-10 is raised(P<0.01).Conclusions: Shi-re-bi Tablet can regulate the balance of T lymphocyte and cytokine network
and thus may be its mechanism for treatment of rheumatoid arthritis.
Editorial Explanation of Guidelines for Establishing Animal Models of Rheumatoid Arthritis with Cold-dampness Obstruction Syndrome and Dampness-heat Obstruction Syndrome
Guidelines for Establishing Animal Models of Rheumatoid Arthritis with Cold-dampness Obstruction Syndrome and Dampness-heat Obstruction Syndrome
Clinical Characteristics and Influencing Factors of Rheumatoid Arthritis in Patients with Cold Dampness Obstruction Syndrome
Pathogenesis and Traditional Chinese Medicine Treatment of Rheumatoid Arthritis Based on Theory of "Harmful Hyperactivity and Responding Inhibition"
Curative Effect of Tripterygium wilfordii Polyglycoside Tablets in Treatment of Rheumatoid Arthritis in Real World Based on Propensity Score Matching
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Related Institution
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