Objective:Study the protection of Radix Angelicae Sinensis on liver injury caused by the carbon tetrachloride.Methods: 50 mice were randomly divided into five groups

with were contrast group(Ⅰ)

model group(Ⅱ)

low dose of Radix Angelicae Sinensis group(Ⅲ)

moderate dose(Ⅳ) and high dose(V).Group Ⅲ～Ⅴ were given water extracting-alcohol precipitating solution of Radix Angelicae Sinensis according to the dose of 5

10

20 g·kg-1 by subcutaneous injection respectively

and other two groups were given normal saline at the same volume dose for 6 days.At two hours after the last administration

group Ⅱ～Ⅴwere given the 0.1% paraffin oil solution of carbon tetrachloride by intraperitoneal injection

all the mice were sacrificed after 24 hours and to observe the change of liver tissue(especially mitochondria and endoplasmic reticulum) with electron microscope.Results: Injury degree of mitochondria and endoplasmic reticulum of liver intracellular in Radix Angelicae Sinensis groups were obviously alleviativer than that of the model group.Conclusion: Water extracting-alcohol precipitating solution of Radix Angelicae Sinensis has the function of protecting the mice's acute liver injury caused by carbon tetrachloride.