Preparation and Percutaneous Permeability in vitro of Rouguiyou Cataplasma GAO Peng-fei, YIN Ai-wu
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Preparation and Percutaneous Permeability in vitro of Rouguiyou Cataplasma GAO Peng-fei, YIN Ai-wu
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 6, Pages: 31-34(2010)
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Published:2010
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Preparation and Percutaneous Permeability in vitro of Rouguiyou Cataplasma GAO Peng-fei, YIN Ai-wu[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 31-34.
DOI:
Preparation and Percutaneous Permeability in vitro of Rouguiyou Cataplasma GAO Peng-fei, YIN Ai-wu[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 31-34.DOI:
Preparation and Percutaneous Permeability in vitro of Rouguiyou Cataplasma GAO Peng-fei, YIN Ai-wu
摘要
目的 :优选肉桂油巴布剂配方。 方法 :采用L9(34)正交试验
以初粘力、持粘力、物理性状为衡量指标
进行最佳基质配方筛选;采用Franz扩散池考察处方的体外经皮渗透性
以HPLC 测定肉桂油主要成分桂皮醛的浓度
求其12 h内的渗透量及稳态透皮速率。 结果 :优选肉桂油巴布剂主要基质配方为卡波姆1.3 g、甘油30 g 、聚丙烯酸钠5.5 g
稳态透皮速率J为13.44 μg ·cm-2 ·h-1。 结论 :优选的肉桂油巴布剂配方合理
具有较好的体外经皮渗透性能。
Abstract
Objective : To optimize the matrix formula of Rouguiyou cataplasm. Method : Orthogonal experiment was used to design formula by measuring tack
cohesion and physical properties; percutaneous permeability in vitro was tested by using the franz diffusion cell
the permeation amount of cinnamaldehyde within 12h in vitro was examined by HPLC. Result : The optimal formula was acquired with carbomer 1.3g
glycerol 30 g and PAAS 5.5g
and the percutaneous rate is 13.44 μg ·cm-2 ·h-1. Conclusion : The established preparation technique of cataplasm was feasible
and its percutaneous permeability in vitro was stable.
Preparation and Percutaneous Permeability in vitro of Rouguiyou Cataplasma GAO Peng-fei, YIN Ai-wu
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Related Author
GAO Peng-fei
YIN Ai-wu
ZHANG Qiuyan
LI Ying
GAO Yunxiao
HU Longxiao
YUAN Yue
CHEN Xiaoxiao
Related Institution
Natural History Museum of China
Beijing Key Laboratory of Chinese Materia Pharmacology,Institute of Basic Medical Sciences, Xiyuan Hospital,China Academy of Chinese Medical Sciences
Beijing University of Chinese Medicine
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences
School of Chinese Materia Medica, Beijing University of Chinese Medicine