Study on the in vitro Release and Transdermal Permeability of Zuojin Micro-emulsive Gel and Zuojin Aqueous Gel

QIN Jian1; LIU Shu-zhi2; ZHANG Qiang2; YANG Hua2; DU Mao-bo2; JIN Ri-xian2; YI Hong2; LI Man-ling2

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Study on the in vitro Release and Transdermal Permeability of Zuojin Micro-emulsive Gel and Zuojin Aqueous Gel

更新时间：2024-01-04

- Study on the in vitro Release and Transdermal Permeability of Zuojin Micro-emulsive Gel and Zuojin Aqueous Gel
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 15, Issue 12, Pages: 40-44(2009)
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- Published：2009
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QIN Jian1, LIU Shu-zhi2, ZHANG Qiang2, et al. Study on the in vitro Release and Transdermal Permeability of Zuojin Micro-emulsive Gel and Zuojin Aqueous Gel[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(12): 40-44.
DOI：

QIN Jian1, LIU Shu-zhi2, ZHANG Qiang2, et al. Study on the in vitro Release and Transdermal Permeability of Zuojin Micro-emulsive Gel and Zuojin Aqueous Gel[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(12): 40-44. DOI：

摘要

目的:研究、比较左金微乳凝胶、水凝胶体外释放和经皮渗透特性

探讨微乳凝胶对药物释放及透皮性能的影响。方法:采用改良Franz扩散池

以凝胶中小檗碱、巴马汀、吴茱萸碱、吴茱萸次碱等4种生物碱为评价指标

采用HPLC方法测定接收液中上述4个成分含量。结果:吴茱萸次碱的体外释放速率水凝胶高于微乳凝胶

而吴茱萸碱释放速率微乳凝胶高于水凝胶

其余两个成分体外释放无明显差异。微乳凝胶中吴茱萸碱、巴马汀、小檗碱的经皮渗透速率比水凝胶分别提高了10倍、36倍、26倍

提示微乳凝胶具有明显的经皮渗透优势。两种凝胶中四个指标成分的体外释放和经皮渗透行为均符合零级方程。吴茱萸次碱较为特殊

其在水凝胶中透皮速率比微乳凝胶高1.6倍。结论:微乳凝胶能显著增强药物成分的经皮渗透能力。

Abstract

Objective: To compare the in vitro release and transdermal permeability between Zuojin micro-emulsive gel and Zuojin aqueous gel.Methods: Improved Franz diffusion cell was adopted to research the in vitro release and permeability difference between the two kinds of gels in mouse skin

and HPLC was used to determined the contents of evodiamine

rutaecarpine

palmatine and berberine in the receiving solutions.Result: The release rate of rutaecarpine in the aqueous gel was higher than that of micro-emulsive gel;and the release rate of evodiamine in micro-emulsive gel was higher than that of the aquous gel.The release of palmatine and berberine was no significant difference between two kind of gels.The permeation rate of evodiamine

palmatined and berberine in micro-emulsive gel was 10 times

36 times and 26 times higher than those in the aquous gel respectively.The permeation rate of rutaecarpine in the aqueous gel was 1.6 times higher than that in the micro-emulsive gel.The release and penetration process of four compounds in two kinds of Zuojin gels conformed to zero kinetic equation.Conclusion: Micro-emulsive gel could significantly enhance the transdermal permeability of compound.

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