Effects of Promoting Blood Circulation to Remove Blood Stasis of Puhuang-Wulingzhi Drug Pair in Shaofu Zhuyu Decoction

ZHOU Wei; SU Shu-lan; LIU Pei; HUA Yong-qing; DUAN Jin-ao

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Effects of Promoting Blood Circulation to Remove Blood Stasis of Puhuang-Wulingzhi Drug Pair in Shaofu Zhuyu Decoction

更新时间：2024-09-23

- Effects of Promoting Blood Circulation to Remove Blood Stasis of Puhuang-Wulingzhi Drug Pair in Shaofu Zhuyu Decoction
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 6, Pages: 179-183(2010)
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- Published：2010
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ZHOU Wei, SU Shu-lan, LIU Pei, et al. Effects of Promoting Blood Circulation to Remove Blood Stasis of Puhuang-Wulingzhi Drug Pair in Shaofu Zhuyu Decoction[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 179-183.
DOI：

ZHOU Wei, SU Shu-lan, LIU Pei, et al. Effects of Promoting Blood Circulation to Remove Blood Stasis of Puhuang-Wulingzhi Drug Pair in Shaofu Zhuyu Decoction[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 179-183. DOI：

摘要

目的 :评价少腹逐瘀汤、少腹逐瘀汤减蒲黄-五灵脂及蒲黄-五灵脂药对水提物对大鼠急性血瘀模型血液流变性的影响及体外对家兔血小板聚集及凝血酶时间的影响。方法 :采用大鼠急性血瘀模型评价少腹逐瘀汤、少腹逐瘀汤减蒲黄-五灵脂及蒲黄-五灵脂药对水提物对血液流变性的影响;采用体外实验观察不同提取物对二磷酸腺苷(ADP)诱导的血小板聚集作用及凝血酶时间(TT)法抗凝血作用的影响。结果 :大鼠急性血瘀模型研究结果表明:少腹逐瘀汤能够明显改善急性血瘀SD大鼠全血黏度(P＜0.05)、血沉(P＜0.05);且可以延长TT、凝血酶原时间(PT)和部分活化凝血活酶时间(APTT);而蒲黄-五灵脂药对在降低全血黏度、改善血沉及体外延长家兔血浆凝血时间方面均优于全方减去蒲黄-五灵脂提取物。结论 :少腹逐瘀汤对大鼠急性血瘀模型的血液流变性及体外对家兔血小板聚集及凝血酶时间的影响均有显著作用

且蒲黄五灵脂药对对于全方效应起到主要作用

提示蒲黄-五灵脂药对与全方减去蒲黄-五灵脂药味配伍可能存在一定的增效作用

为揭示该药对对全方活血化瘀效应的贡献提供了一定科学数据。

Abstract

Objective: To evaluate the effects of Shaofu Zhuyu decoction

prescription minus Puhuang -Wulingzhi drug pair and Puhuang -Wulingzhi drug pair on hemorheological parameters in rat mode of acute blood stasis

and the influence on platelet aggregation and clotting time in vitro. Method : Rat mode of acute blood stasis was used to evaluate the Changes in hemorheology

the function of blood coagulation and ovarian. The platelet aggregation was tested with Born's method and thrombin time (TT) method in vitro was established to determine the clotting time. Result : The results stated that Shaofu Zhuyu decoction showed significant improvements in the hemorheological indexes of rats in the model of blood stasis and regulation for the secret function of rat ovarian. Meanwhile

the result of vitro assay showed that Shaofu Zhuyu Decoction had significantly inhibitory effects on the platelet aggregation and prolonged clotting time. The effects of Puhuang -Wulingzhi drug pairare superior to the group of prescription minus Puhuang -Wulingzhi drug pair on reducing whole blood viscosity

plasma viscosity and extending clotting time in vitro. Conclusion: Shaofu Zhuyu decoction can improve the indexes of hemorheology in rat model of blood stasis

and showed significant inhibitory effect on platelet aggregation and clotting time. Furthermore

Puhuang -Wulingzhi drug pair plays the major role in the biological effect for the whole prescription.

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Related Institution

Jiangsu Key Laboratory for TCM formulae Reasearch,Nanjing University of Chinese Medicine

Jiangsu Key Laboratory for Traditional Chinese Medicine Formulae Reasearch, Nanjing University of Chinese Medicine

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