Influence of Huoluoyuyinfang Decoction Upon Rage Receptor Expression in Rat Brain Tissue with Diabetes and Cerebral Embolism
|更新时间:2024-01-04
|
Influence of Huoluoyuyinfang Decoction Upon Rage Receptor Expression in Rat Brain Tissue with Diabetes and Cerebral Embolism
Chinese Journal of Experimental Traditional Medical FormulaeVol. 15, Issue 4, Pages: 50-53(2009)
作者机构:
作者简介:
基金信息:
DOI:
CLC:
Published:2009
稿件说明:
移动端阅览
LI Feng-yi1, LI Fu-rong2, ZHANG Ji-guo2, et al. Influence of Huoluoyuyinfang Decoction Upon Rage Receptor Expression in Rat Brain Tissue with Diabetes and Cerebral Embolism[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(4): 50-53.
DOI:
LI Feng-yi1, LI Fu-rong2, ZHANG Ji-guo2, et al. Influence of Huoluoyuyinfang Decoction Upon Rage Receptor Expression in Rat Brain Tissue with Diabetes and Cerebral Embolism[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(4): 50-53.DOI:
Influence of Huoluoyuyinfang Decoction Upon Rage Receptor Expression in Rat Brain Tissue with Diabetes and Cerebral Embolism
Objective:To set up a rat model of diabetic cerebral embolism
in order to observe and compare the expression of advanced glycosylation end product receptor(RAGE) in rat brain and effects about Huoluoyuyinfang Decoction on it.Methods: SD rats were fed on a diet enriched in fat and fructose and the rats were injected intrapertoneally with a low-dose streptozocin(STZ) to induce hyperglycemia.Then set up middle cerebral artery occlusion(MCAO) by ligation.Morphology and other methods were applied to observe the protective effect of Huoluoyuyinfang at different doses and differrnt times.Immunohistochemical ABC method was employed to observe the effect of Huoluoyuyinfang on RAGE in rat brain of cerebral infarction due to diabetes.Results: For different dosages and stages
the RAGE expression was significantly decreased in the brain tissue by Huoluoyuyinfang.Clusion: Huoluoyuyinfang Decoction may decrease the expression of RAGE and play an important protecting role against diabetic neurological impairment.
Establishment and Evaluation of Mouse Model of Cerebral Infarction with Qi and Yin Deficiency Syndrome Based on Metabolomics
Research Progress on Signaling Pathways Related to Treatment of Diabetic Cognitive Dysfunction with Traditional Chinese Medicine: A Review
Traditional Chinese Medicine Treatment for Diabetes and Its Complications: A Review
Pathological Mechanism of Diabetes Based on NF-κB Signaling Pathway and Traditional Chinese Medicine Intervention: A Review
Pathogenesis of Diabetes from Theory of Spleen Deficiency Causing Diabetes Based on Intestinal Innate Immunity
Related Author
YUAN Yue
GAO Yunxiao
ZHANG Qiuyan
CHEN Xiaoxiao
SHI Yali
HU Longxiao
LIU Jianxun
REN Junguo
Related Institution
Beijing Key Laboratory of Chinese Materia Pharmacology,National Clinical Research Center of Traditional Chinese Medicine for Cardiovascular Diseases,Institute of Basic Medical Sciences, Xiyuan Hospital,China Academy of Chinese Medical Sciences
Natural History Museum of China
Shandong Academy of Chinese Medicine
Traditional Chinese Medicine(TCM);Analysis of Key Disciplines of State Administration of TCM
The First Clinical Medical College,Shandong University of Chinese Medicine