Relationship Among Dosage,Effect and Toxicity of the Ingredients in a Chinese Herbal Formula

Wen Le-xi; WEI Fei-yue

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Relationship Among Dosage,Effect and Toxicity of the Ingredients in a Chinese Herbal Formula

更新时间：2024-01-04

- Relationship Among Dosage,Effect and Toxicity of the Ingredients in a Chinese Herbal Formula
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 15, Issue 5, Pages: 84-87(2009)
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- Published：2009
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Wen Le-xi, WEI Fei-yue. Relationship Among Dosage,Effect and Toxicity of the Ingredients in a Chinese Herbal Formula[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(5): 84-87.
DOI：

Wen Le-xi, WEI Fei-yue. Relationship Among Dosage,Effect and Toxicity of the Ingredients in a Chinese Herbal Formula[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(5): 84-87. DOI：

摘要

方剂中药物的剂量与方剂效用、毒性关系密切。方剂药物的总量、主药用量、药物间的用量比例变化

不仅可改变方剂药力的大小

而且能改变方剂的功用主治。方剂中药物用量恰当

可“化毒为药”;而用量不当

则“变药为毒”。为使方剂毒性最小化而疗效最大化

应加强中药

特别是方剂量效曲线关系以及量毒关系的研究、开展中药中毒谱研究和中药复方安全性评价研究、注重对临床报道的收集、分析。

Abstract

In a formula

the dosage of an ingredient is closely related with its effect and toxicity. Any change in the total weight of a formula

weight of the main herbs or the ratios between herbs can change not only the power of the recipe but also its actions and indications. That is why proper dosages can make the toxic herb a remedial one

whereas wrong dosages can make a remedial herb toxic.To use the minimum dose and get the maximum effect

more studies should be made as to the Chinese herbs

especially the dose-response relationship among dosage

effect and toxicity. The spectra of poisoning and the safety of a compound preparation should be evaluated as well. In addition

attenton should be paid to the collection and analyses of the clinic reports.

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