Caco-2 Cell Model and Its Application in the Absorption and Transportation Research of Chinese Materia Medica
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Caco-2 Cell Model and Its Application in the Absorption and Transportation Research of Chinese Materia Medica
Chinese Journal of Experimental Traditional Medical FormulaeVol. 15, Issue 5, Pages: 79-83(2009)
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Published:2009
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ZHAO Jing, LIANG Ai-hua. Caco-2 Cell Model and Its Application in the Absorption and Transportation Research of Chinese Materia Medica[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(5): 79-83.
DOI:
ZHAO Jing, LIANG Ai-hua. Caco-2 Cell Model and Its Application in the Absorption and Transportation Research of Chinese Materia Medica[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(5): 79-83.DOI:
Caco-2 Cell Model and Its Application in the Absorption and Transportation Research of Chinese Materia Medica
The Caco-2 cell model is an in vitro model for screening drug oral absorption characteristics. It has been used widely for evaluating drug absorption characteristics and transportation mechanism.The authors describ the Caco-2 cells culture and how to establish and verify the cell monolayer model.The mechanism of its application in the drug absorption and transportation study is investigated.The applications for passive transportation of Chinese material medica
vector mediated active transportation
efflux mechanism and the drug-drug interaction in the absorption process are discussed in detail.The efficiency on the absorption and transportation mechanism research of Chinese material medica for the Caco-2 cell is evaluated.Finally
the prospect of the cell model in future application is put forward.
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Related Institution
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education,State Key Laboratory of Component-based Chinese Medicine,Haihe Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine
School of Pharmacy,School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine
Tianjin Modern Innovation TCM Technology Co. Ltd.
College of Pharmaceutical Engineering of Traditional Chinese Medicine (TCM), Tianjin University of TCM
College of Pharmacy,Hunan University of Chinese Medicine,Hunan Provincial Key Laboratory of Druggability and Preparation Modification for Chinese Materia Medica, Laboratory of Supramolecular Mechanism and Mathematic-physics Characterization of Traditional Chinese Medicine(TCM),Property and Pharmacodynamic Key Laboratory of TCM, National Administration of TCM,State Key Laboratory of Chinese Materia Medica Intelligence and Drug Innovation (Cultivation)